CD39 and CD73 in immunity and inflammation
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TLDR
The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.About:
This article is published in Trends in Molecular Medicine.The article was published on 2013-06-01 and is currently open access. It has received 858 citations till now.read more
Citations
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Journal ArticleDOI
Common Features of Regulatory T Cell Specialization During Th1 Responses.
Katharina Littringer,Claudia Moresi,Nikolas Rakebrandt,Xiaobei Zhou,Xiaobei Zhou,Michelle Schorer,Tamas Dolowschiak,Florian R. Kirchner,Felix Rost,Christian W. Keller,Donal McHugh,Salomé LeibundGut-Landmann,Mark D. Robinson,Mark D. Robinson,Nicole Joller +14 more
TL;DR: The novel co-inhibitory receptor CD85k is identified as a functional predictor for Treg-mediated suppression specifically of Th1 responses, which could be explored therapeutically for selective immune suppression in autoimmunity.
Journal ArticleDOI
The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases.
TL;DR: The final aim is to consider the role of adenosinergic ectoenzymes and ADO receptors as novel therapeutic targets for selected diseases.
Journal ArticleDOI
Possible role of hemichannels in cancer.
TL;DR: The evidence regarding the involvement of hemichannels in cell proliferation and migration, as well as their possible role in the anti-tumor immune responses are summarized and summarized.
Journal ArticleDOI
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Neeraja Kulkarni,Heikrujam Thoihen Meitei,Sandip Ashok Sonar,Praveen Sharma,Vikkarasan Rehman Mujeeb,Sharad Srivastava,Ramanamurthy Boppana,Girdhari Lal +7 more
TL;DR: A new role of CCR6 signaling in the differentiation of iTregs during inflammation and gut autoimmunity is identified and induced phosphorylation of Akt, mTOR, and STAT3 molecules in T cells.
Journal ArticleDOI
A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies
Alexander K. Tsai,Asra Y. Khan,Christina E. Worgo,Lucy L. Wang,Yuanyuan Liang,Eduardo Davila +5 more
TL;DR: High-throughput flow cytometry-based screening reveals that Reg and NU7441 influence the immunobiology of both tumor cells and T cells and enhance the efficacy of various immunotherapies.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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How regulatory T cells work.
TL;DR: The hypothesis that effector T cells may not be 'innocent' parties in this suppressive process and might in fact potentiate TReg-cell function is proposed.
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Journal ArticleDOI
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
Journal ArticleDOI
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
TL;DR: In the 10 years since the previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations, but there have been so many other developments that an update is needed.