Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
Bidisha Sinha,Darius Vasco Köster,Darius Vasco Köster,Richard Ruez,Richard Ruez,Pauline Gonnord,Pauline Gonnord,Michele Bastiani,Daniel Abankwa,Radu V. Stan,Gillian Butler-Browne,Benoît Vedie,Ludger Johannes,Ludger Johannes,Nobuhiro Morone,Robert G. Parton,Graça Raposo,Graça Raposo,Pierre Sens,Christophe Lamaze,Christophe Lamaze,Pierre Nassoy,Pierre Nassoy +22 more
TLDR
Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress.About:
This article is published in Cell.The article was published on 2011-02-04 and is currently open access. It has received 763 citations till now. The article focuses on the topics: Caveolae & Caveolin.read more
Citations
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Caveolae as plasma membrane sensors, protectors and organizers
TL;DR: The importance of caveolae as protective elements in the plasma membrane, and as membrane organizers and sensors, is highlighted by links between Caveolae dysfunction and human diseases, including muscular dystrophies and cancer.
Journal ArticleDOI
Use the force: membrane tension as an organizer of cell shape and motility.
TL;DR: Current understanding of how changes in PM tension regulate cell shape and movement is reviewed, as well as how cells sense PM tension.
Journal ArticleDOI
Clathrin-Independent Pathways of Endocytosis
TL;DR: This review explores pathways of endocytosis that occur in the absence of clathrin that are likely to play key roles in the regulation of plasma membrane area and tension and also control the availability of membrane during cell migration.
Journal ArticleDOI
Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.
TL;DR: Techniques for membrane disruption-based intracellular delivery from 1911 until the present achieve rapid, direct, and universal delivery of almost any cargo molecule or material that can be dispersed in solution.
Journal ArticleDOI
Mechanical feedback between membrane tension and dynamics
TL;DR: The importance of membrane area and of tension as a master integrator of cell functions, particularly for membrane traffic, is discussed.
References
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Caveolin, a protein component of caveolae membrane coats.
Karen G. Rothberg,John E. Heuser,William C. Donzell,Yun-shu Ying,John R. Glenney,Richard G.W. Anderson +5 more
TL;DR: Structural analysis of the striated coat of caveolae reveals a third type of coated membrane specialization that is involved in molecular transport and is named caveolin, suggesting that this molecule is a component of the coat.
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Local force and geometry sensing regulate cell functions.
Viola Vogel,Michael P. Sheetz +1 more
TL;DR: Tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms of eukaryotic cells.
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Dynasore, a Cell-Permeable Inhibitor of Dynamin
Eric Macia,Marcelo Ehrlich,Ramiro Massol,Emmanuel Boucrot,Christian Brunner,Tomas Kirchhausen +5 more
TL;DR: Dynamin acts at two steps during clathrin coat formation; GTP hydrolysis is probably needed at both steps; Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition.
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Functional Significance of Cell Volume Regulatory Mechanisms
Florian Lang,Gillian L. Busch,Markus Ritter,Harald Völkl,Siegfried Waldegger,Erich Gulbins,Dieter Häussinger +6 more
TL;DR: Cell volume may be considered a second message in the transmission of hormonal signals, and alterations of cell volume and volume regulatory mechanisms participate in a wide variety of cellular functions including epithelial transport, metabolism, excitation, hormone release, migration, cell proliferation, and cell death.