Journal ArticleDOI
Caveolae as plasma membrane sensors, protectors and organizers
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TLDR
The importance of caveolae as protective elements in the plasma membrane, and as membrane organizers and sensors, is highlighted by links between Caveolae dysfunction and human diseases, including muscular dystrophies and cancer.Abstract:
Caveolae are submicroscopic, plasma membrane pits that are abundant in many mammalian cell types. The past few years have seen a quantum leap in our understanding of the formation, dynamics and functions of these enigmatic structures. Caveolae have now emerged as vital plasma membrane sensors that can respond to plasma membrane stresses and remodel the extracellular environment. Caveolae at the plasma membrane can be removed by endocytosis to regulate their surface density or can be disassembled and their structural components degraded. Coat proteins, called cavins, work together with caveolins to regulate the formation of caveolae but also have the potential to dynamically transmit signals that originate in caveolae to various cellular destinations. The importance of caveolae as protective elements in the plasma membrane, and as membrane organizers and sensors, is highlighted by links between caveolae dysfunction and human diseases, including muscular dystrophies and cancer.read more
Citations
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Journal ArticleDOI
Caveolin, a protein component of caveolae membrane coats.
Karen G. Rothberg,John E. Heuser,William C. Donzell,Yun-shu Ying,John R. Glenney,Richard G.W. Anderson +5 more
TL;DR: Structural analysis of the striated coat of caveolae reveals a third type of coated membrane specialization that is involved in molecular transport and is named caveolin, suggesting that this molecule is a component of the coat.
Journal ArticleDOI
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Marek Drab,Paul Verkade,Marlies Elger,Michael Kasper,Matthias Lohn,Matthias Lohn,Birgit Lauterbach,Birgit Lauterbach,Jan Menne,Carsten Lindschau,Carsten Lindschau,Fanny Mende,Friedrich C. Luft,Andreas Schedl,Hermann Haller,Teymuras V. Kurzchalia +15 more
TL;DR: By targeted disruption of caveolin-1, the main protein component of caveolae, mice that lacked Caveolae were generated, causing aberrations in endothelium-dependent relaxation, contractility, and maintenance of myogenic tone and indicating a fundamental role in organizing multiple signaling pathways in the cell.
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