Cholesterol binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1
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TLDR
Two stages of cholesterol handling in late endosomal compartments are proposed: first, cholesterol enters MLN64/ABCA3-positive compartments from where it can be recycled to the plasma membrane, and later, cholesterol entering ORP1L/NPC1 endosomes that mediate cholesterol export to the endoplasmic reticulum.About:
This article is published in Journal of Lipid Research.The article was published on 2013-08-01 and is currently open access. It has received 91 citations till now. The article focuses on the topics: Cholesterol binding & Endosome.read more
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Structure and function of ER membrane contact sites with other organelles.
TL;DR: The structure and functions of MCSs are described, primarily focusing on contacts of the ER with mitochondria and endosomes, as well as engaging in organelle biogenesis and dynamics.
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Here, there, and everywhere: The importance of ER membrane contact sites
TL;DR: It's all about your contacts Membrane contact sites have recently come to the fore of the understanding of interorganelle communication and how these important structures help to promote a variety of key functions, including organelle division and lipid transfer.
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The life cycle of phagosomes: formation, maturation, and resolution
TL;DR: The molecular events underlying these stages are being unraveled and the current state of knowledge is briefly summarized in this article.
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Complex lipid trafficking in Niemann-Pick disease type C.
TL;DR: A reappraisal of lipid storage and lysosomal enzymes activities in tissues/cells from NPC patients and animal models is provided, with emphasis on differences between systemic organs and the brain.
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STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.
Fabien Alpy,Adrien Rousseau,Yannick Schwab,Yannick Schwab,François Legueux,Isabelle Stoll,Corinne Wendling,Coralie Spiegelhalter,Pascal Kessler,Carole Mathelin,Marie-Christine Rio,Tim P. Levine,Catherine Tomasetto +12 more
TL;DR: The identification of proteins involved in inter-organellar interaction in the formation of MCSs involving late-endosomes including endogenous LE–ER MCS is reported.
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The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors
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