Chromatin, gene silencing and HIV latency
Hoi Ping Mok,Andrew Ml Lever +1 more
TLDR
The relationship of viral latency to gene-silencing mechanisms is reviewed, and it is shown that at least two gene- silencing mechanisms are used against the human immuno-deficiency virus.Abstract:
One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral latency to gene-silencing mechanisms.read more
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Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
Leor S. Weinberger,John C. Burnett,John C. Burnett,Jared E. Toettcher,Adam P. Arkin,Adam P. Arkin,David V. Schaffer,David V. Schaffer +7 more
TL;DR: Stochastic computational modeling successfully accounted for PheB and correctly predicted the dynamics of a Tat mutant that were subsequently confirmed by experiment, illustrating the importance of stochastic fluctuations in gene expression in a mammalian system.
Journal ArticleDOI
Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency
TL;DR: The results support pharmaceutical control of histone modifying enzymes as a strategy for controlling herpesvirus infections by showing that infection by the α-herpesviruses, herpes simplex virus (HSV) and varicella zoster virus (VZV), results in the rapid accumulation of chromatin bearing repressive histone H3 Lys9 methylation.
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Integration site selection by retroviruses and transposable elements in eukaryotes
TL;DR: High-throughput profiling of integration sites by next-generation sequencing, combined with large-scale genomic data mining and cellular or biochemical approaches, has revealed that the insertions are usually non-random.
Journal ArticleDOI
An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription.
Sheena Saayman,Amanda Ackley,Anne-Marie W. Turner,Marylinda Famiglietti,Alberto Bosque,Matthew Clemson,Vicente Planelles,Kevin V. Morris,Kevin V. Morris +8 more
TL;DR: It is found that this viral expressed antisense lncRNA is involved in modulating human immunodeficiency virus gene expression and that this regulatory effect is due to an alteration in the epigenetic landscape at the viral promoter.
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Snapshots: chromatin control of viral infection.
David M. Knipe,Paul M. Lieberman,Jae U. Jung,Alison A. McBride,Kevin V. Morris,Melanie Ott,David M. Margolis,Amelia Nieto,Michael Nevels,Robin J. Parks,Thomas M. Kristie +10 more
TL;DR: This review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment, focusing on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, and control of viral latency-reactivation cycles.
References
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HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
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