Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Submandibular salivary gland transfer: a pitfall in head and neck imaging with F-18 FDG PET/CT.
TL;DR: 2 cases of patients with surgically transferred submandibular glands are reported, which highlight a potential pitfall in the interpretation of PET/CT of the head and neck region in oncologic patients.
Salivary gland stem cells
TL;DR: In this paper, the authors present an onderzoek on the identificatie, karakterisering and functionele mogelijkheden van knaagdieren speekselklier stamcellen.
Journal Article
The mandibular salivary gland microscopic morphology of the adult African giant pouched rat (Cricetomys gambianus, Waterhouse-1840)
TL;DR: For the first time, the normal histology of submandibular salivary gland in the giant pouched rat is documents, filling the knowledge gap that will help further research especially on the role of myoepihelial cells in the secretory glands tumours.
Journal ArticleDOI
A Computational Text Mining-Guided Meta-Analysis Approach to Identify Potential Xerostomia Drug Targets
Micaela F. Beckman,Elizabeth J. Brennan,Chika K. Igba,Michael T. Brennan,Farah Bahrani Mougeot,Jean-Luc C. Mougeot +5 more
TL;DR: Text-mining tools are used to investigate xerostomia and dry mouth concepts, identify associated molecular interactions involving genes as candidate drug targets, and determine how drugs currently used in clinical trials may impact these genes and associated pathways.
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
Gregory M. Preston,Peter Agre +1 more
TL;DR: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.
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Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
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