Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Quality of Life, Psychological Distress, and Nutritional Status of Polish Patients with Head and Neck Cancer Treated with Radiotherapy
TL;DR: In this paper , the early impact of radiotherapy on HRQoL outcomes, psychological distress, nutritional status, and overall performance of patients with head and neck cancer (HNC) was assessed.
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The Role of mTOR and Injury in Developing Salispheres
TL;DR: In this paper , the role of rapamycin and injury in the formation and development of salispheres was investigated. But, the results indicated that active mTOR was not responsible for the morphological modification, but other unexplored factors were involved.
Journal ArticleDOI
Radioprotective effect of endogenous melatonin secretion associated with the circadian rhythm in irradiated rats.
Sema Yilmaz Rakici,Levent Tumkaya,Ozlem Celebi Edirvanli,Ufuk Yazici,Engin Dursun,Medeni Arpa,Tolga Mercantepe +6 more
TL;DR: Consideration of endogenous melatonin secretion associated with the circadian rhythm may offer new therapeutic solutions for the complications of head and neck radiotherapy.
Journal ArticleDOI
Ernährung im Kontext der Strahlentherapie
Oliver Micke,Jens Büntzel +1 more
TL;DR: In this article, the authors discuss the Wechselwirkung zwischen Ernahrung and Bestrahlung in 4-Thesen zusammenfassen: 1.
Book ChapterDOI
Palliative Care Therapies
TL;DR: Palliative care is a specialized care area bounded to deliver health care facilities to patients who suffer from direct, indirect symptoms, unmet needs, for prevention and relief suffering from psychological issues mainly emotional issues (depression, anxiety, and delirium) and physiological issues like (nausea, vomiting, fatigue, xerostomia, headache, osteoradionecrosis, hemoptysis, dyspnea, taste loss, and pain) as mentioned in this paper .
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
Gregory M. Preston,Peter Agre +1 more
TL;DR: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.
Journal ArticleDOI
Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
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