Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Potential of salivary gland stem cells in regenerative medicine
TL;DR: Weefselspecifieke volwassen stamcellen hebben de aandacht getrokken van de biomedische gemeenschap doordat ze in staat zijn om alle celtypes van een orgaan te vormen waardoor ze bruikbaar zouden kunnen zijn voor stamceltherapie.
Posted ContentDOI
LINCS gene expression signatures analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1
TL;DR: Bosutinib was proposed to be a promising radiosensitizer as its administration markedly reduced the dosages of both the drug and ionizing radiation and was associated with fewer adverse drug reactions, and eIF4G1 could be a key target of bosut inib through which it regulates DNA damage induced by ionizing Radiation.
Book ChapterDOI
Future Prevention and Treatment of Radiation-Induced Hyposalivation
TL;DR: Stem cell therapy seems to have the highest potential as in preclinical studies it has been shown to restore glandular homoeostasis and long-term regenerative capacity, however, less radiation dose as possible with proton therapy may be the best way to prevent hyposalivation.
Journal ArticleDOI
Submandibular gland - The victim of neck dissection.
Posted ContentDOI
Sox9 + cells are required for salivary gland regeneration after radiation damage via the Wnt/β-catenin pathway
Kristin Johnston Largen,Xiuyun Xu,Xiong Gan,Ming Zhang,Jiaxiang Xie,Shuang Chen,Kang Li,Jingting Li,Yong Bao,Cheng Wang,Demeng Chen +10 more
TL;DR: The research indicated that regenerative therapy targeting Sox9+ cells is a promising method to solve the radiation induced salivary gland injury.
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
Gregory M. Preston,Peter Agre +1 more
TL;DR: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.
Journal ArticleDOI
Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
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A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact
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