Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Vitamin E protects salivary glands dysfunction induced by ionizing radiation in rats.
Seyed Mohammad Abedi,Fateme Yarmand,Mina Motallebnejad,Maryam Seyedmajidi,Dariush Moslemi,Manouchehr Ashrafpour,Ali Bijani,Ali Akbar Moghadamnia,Alireza Mardanshahi,Seyed Jalal Hosseinimehr +9 more
TL;DR: Vitamin E is a promising radioprotective agent for patients who receive radiation in head and neck cancer therapy, indicating protective effects of vitamin E against salivary gland dysfunction induced by gamma radiation.
Journal ArticleDOI
Current and Future Perspectives of the Use of Organoids in Radiobiology.
Peter W. Nagle,Robert P. Coppes +1 more
TL;DR: How organoids, three-dimensional tissue-resembling structures derived from tissue-resident, embryonic or induced pluripotent stem cells, overcome the limitations of these models and thus have a growing importance in the field of radiation biology research are discussed.
Journal ArticleDOI
Persistent disruption of lateral junctional complexes and actin cytoskeleton in parotid salivary glands following radiation treatment
TL;DR: It is illustrated that radiation induces a ROCK-dependent disruption of the cadherin-catenin complex and alters F-actin organization at stages of damage when hyposalivation is observed.
Journal ArticleDOI
Cell culture of differentiated human salivary epithelial cells in a serum-free and scalable suspension system: The salivary functional units model.
You Jung Seo,Maria Alberta Lilliu,Maria Alberta Lilliu,Ghada Abu Elghanam,Ghada Abu Elghanam,Thomas T. Nguyen,Thomas T. Nguyen,Younan Liu,J. Lee,J. Lee,John F. Presley,Anthony Zeitouni,Michel El-Hakim,Simon D. Tran +13 more
TL;DR: A serum‐free scalable suspension culture system that grows partially digested human salivary tissue filtrates composing of acinar and ductal cells attached to their native extracellular matrix components while retaining their 3D in vivo spatial organization is devised; it is found that the cells could still survive and grow into largerSalivary spheroids through cell proliferation and aggregation for 5 to 10 days within the oxygen diffusion rates in vitro.
Journal ArticleDOI
Three‐dimensional organotypic culture of human salivary glands: the slice culture model
Xinyun Su,Xinyun Su,Dongdong Fang,Younan Liu,Murali Ramamoorthi,Anthony Zeitouni,Wenxia Chen,Simon D. Tran +7 more
TL;DR: The human salivary 3D organotypic slice culture model kept cells alive ex vivo for 14 days as well as maintaining their 3D morphology and physiological functions.
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
Gregory M. Preston,Peter Agre +1 more
TL;DR: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.
Journal ArticleDOI
Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
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