Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Anatomy and Histology of Rodent and Human Major Salivary Glands: —Overview of the Japan Salivary Gland Society-Sponsored Workshop—
TL;DR: A review of the major salivary glands of humans and rodents can be found in this paper, where the authors describe the macroscopic findings on the salivial glands of rodents and the microscopic differences between those of humans.
Journal ArticleDOI
Parasympathetic stimulation improves epithelial organ regeneration
Sarah M. Knox,Isabelle M.A. Lombaert,Candace L. Haddox,Shaun R. Abrams,Ana P. Cotrim,Adrian J. Wilson,Matthew P. Hoffman +6 more
TL;DR: It is shown that restoring parasympathetic function with the neurotrophic factor neurturin increases epithelial organ regeneration after damage, and the concept may be applicable for other organs where parASYmpathetic innervation influences their function.
Journal ArticleDOI
Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols
Judith A. E. M. Zecha,Judith E. Raber-Durlacher,Raj G. Nair,Joel B. Epstein,Joel B. Epstein,Sharon Elad,Michael R. Hamblin,Michael R. Hamblin,Andrei Barasch,Cesar A. Migliorati,Dan M.J. Milstein,Marie Thérèse Genot,Liset Lansaat,Ron van der Brink,Josep Arnabat-Domínguez,Lisette van der Molen,Irene Jacobi,Judi N.A. van Diessen,Jan de Lange,Ludi E. Smeele,Ludi E. Smeele,Mark M. Schubert,Rene Jean Bensadoun +22 more
TL;DR: PBM may have a role in supportive care for a broad range of complications associated with the treatment of HNC with CRT with suggested PBM irradiation and dosimetric parameters, which are potentially effective for these complications are suggested to provide guidance for well-designed future studies.
Journal ArticleDOI
Salivary Gland Homeostasis Is Maintained through Acinar Cell Self-Duplication
TL;DR: The results support a revised model for salivary gland homeostasis based predominantly on self-duplication of acinar cells, rather than on differentiation of stem cells.
Journal ArticleDOI
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.
Bruce J. Baum,Ilias Alevizos,Changyu Zheng,Ana P. Cotrim,Shuying Liu,Linda McCullagh,Corinne M. Goldsmith,Peter D. Burbelo,Deborah Citrin,James B. Mitchell,Liesl Nottingham,Susan F. Rudy,Carter Van Waes,Millie Whatley,Jaime S. Brahim,John A. Chiorini,Stamatina Danielides,R. James Turner,Nicholas J. Patronas,Clara C. Chen,Nikolay P. Nikolov,Gabor G. Illei +21 more
TL;DR: In this paper, the safety and biologic efficacy of serotype 5, adenoviral-mediated aquaporin-1 cDNA transfer to a single previously irradiated parotid gland were evaluated.
References
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Journal Article
[Radiation-induced sialadenitis. Stage classification and immunohistology].
Dreyer Jo,Sakuma Y,Seifert G +2 more
TL;DR: The course of radiation-induced sialadenitis in 58 cases in the salivary gland registry was subjected to pathohistological and immunohistochemical analysis and shows an increased reaction in the ductal system during stages II and III, while the amylase reaction decreases or is absent, as would be expected with increasing parenchymal atrophy.
Journal ArticleDOI
Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment
Fred R. Burlage,Judith M. Roesink,Hette Faber,Arjan Vissink,Johannes A. Langendijk,Harm H. Kampinga,Robert P. Coppes +6 more
TL;DR: Protection of parotid gland function was seen in the early-intermediate phase after 15 Gy and in the late phase (>120 days) after 10 and 15 Gy, and a stimulatory effect of pilocarpine on the non-irradiated gland resulted in a significant increase in total saliva secretion.
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