Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Book ChapterDOI
Chapitre 2 – Complications et séquelles de la radiothérapie
P. Giraud,J. Thariat +1 more
Journal ArticleDOI
Feasibility of DW-MRI analysis of salivary glands during head and neck radiotherapy
TL;DR: In this article, the authors evaluated the feasibility of measuring apparent diffusion coefficient (ADC) in the major salivary glands and described the observed changes in volume and ADC during RT.
Journal ArticleDOI
Study on anatomy and postnatal development of sublingual salivary glands in Black Bengal goat
TL;DR: Along the advancement of age the size of lobes and lobules are increased, the lumens of the mucous acini reduced in size, nuclei of the cells became flattened the zymogenic granules increased gradually, and in day old kid, the acini have distinct lumen.
Posted ContentDOI
scRNAseq of healthy and irradiated mouse parotid glands highlights crosstalk between immune and secretory cells during chronic injury
Brenna A. Rheinheimer,Mary C. Pasquale,Kirsten H. Limesand,Matthew P. Hoffman,Alejandro Martinez Chibly +4 more
TL;DR: In this article , the authors identify a population of epithelial cells in the parotid gland defined by expression of Etv1, which may be an acinar cell precursor and thus may respond to myoepithelial cell-derived growth factor ligands.
Posted ContentDOI
Regulation of Myoepithelial Differentiation in 3-Dimensional Culture
Renee F. Thiemann,Scott Varney,Nicholas Moskwa,John M. Lamar,Melinda Larsen,Susan E. LaFlamme +5 more
TL;DR: In this article, the authors demonstrate that the pattern of TAZ expression in the epithelial compartment of the differentiating murine salivary gland correlates with the expression of the myoepithelial marker alpha-SMA.
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
Gregory M. Preston,Peter Agre +1 more
TL;DR: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.
Journal ArticleDOI
Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
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