Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers
Arjan Vissink,James B. Mitchell,Bruce J. Baum,Kirsten H. Limesand,Siri Beier Jensen,Philip C. Fox,Linda S. Elting,Johannes A. Langendijk,Robert P. Coppes,Mary E. Reyland +9 more
TLDR
This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivARY gland hypofunction and xerostomia.Abstract:
The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy.read more
Citations
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Concurrent transient activation of Wnt/β-catenin pathway prevents radiation damage to salivary glands.
TL;DR: It is suggested that concurrent transient activation of the Wnt/β-catenin pathway could prevent radiation-induced salivary gland dysfunction following radiation by suppressing apoptosis and preserving functionalsalivary stem/progenitor cells.
Journal ArticleDOI
Interactions between developing nerves and salivary glands.
TL;DR: This work will provide a brief overview of the neuroanatomy of the salivary glands and discuss recent literature that begins to integrate neurobiology with epithelial organogenesis, which may provide paradigms for exploring these interactions in other organ systems.
Journal ArticleDOI
Xerostomia in patients on chronic hemodialysis
Maurizio Bossola,Luigi Tazza +1 more
TL;DR: Xerostomia remains a frustrating symptom for patients on hemodialysis, and further efforts should be made to find an effective treatment for it in the near future.
Journal ArticleDOI
Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction
Xibao Liu,Ana P. Cotrim,Leyla Teos,Changyu Zheng,William D. Swaim,James R. Mitchell,Yasuo Mori,Indu S. Ambudkar +7 more
TL;DR: It is demonstrated that TRPM2 is activated by irradiation, via PARP1 activation, and contributes to irreversible loss of salivary gland function.
Journal ArticleDOI
Systematic review of miscellaneous agents for the management of oral mucositis in cancer patients
Siri Beier Jensen,Virginia Jarvis,Yehuda Zadik,Yehuda Zadik,Andrei Barasch,Anura Ariyawardana,Anura Ariyawardana,Allan Hovan,Noam Yarom,Noam Yarom,Rajesh V. Lalla,Joanne M. Bowen,Sharon Elad,Isoo +13 more
TL;DR: None of the agents reviewed was determined to be effective for the prevention or treatment of oral mucositis, and two agents, pilocarpine and pentoxifylline, were determination to be ineffective, in the populations listed above.
References
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Journal ArticleDOI
Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer
TL;DR: Dose/volume/function relationships in the parotid glands are characterized by dose and volume thresholds, steep dose/response relationships when the thresholds are reached, and a maximal volume dependence parameter in the NTCP model.
Journal ArticleDOI
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
Gregory M. Preston,Peter Agre +1 more
TL;DR: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.
Journal ArticleDOI
Oral Sequelae of Head and Neck Radiotherapy
TL;DR: In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.
Journal ArticleDOI
Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
Journal ArticleDOI
Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer
Avraham Eisbruch,Hyungjin Myra Kim,Jeffrey E. Terrell,Jeffrey E. Terrell,Lon H. Marsh,Laura A. Dawson,Jonathan A. Ship +6 more
TL;DR: An improvement over time in xerostomia, occurring in tandem with rising salivary production from the spared major Salivary glands, suggests a long-term clinical benefit from their sparing.
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