Clinical validation of the FLIP algorithm and the SAF score in patients with non-alcoholic fatty liver disease
Fabio Nascimbeni,Fabio Nascimbeni,Fabio Nascimbeni,P. Bedossa,L. Fedchuk,Raluca Pais,Raluca Pais,Frédéric Charlotte,Pascal Lebray,Thierry Poynard,Vlad Ratziu,Vlad Ratziu,Vlad Ratziu +12 more
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TLDR
The FLIP algorithm/SAF score, although based on purely morphological grounds, are clinically relevant as they identify patients with distinct clinical and biological profiles of disease severity as well as positive linear trends existed between NASH or severe disease and increasing BMI and HOMA-IR.About:
This article is published in Journal of Hepatology.The article was published on 2020-05-01 and is currently open access. It has received 45 citations till now. The article focuses on the topics: Fatty liver & Steatohepatitis.read more
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The Asian pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease
Mohammed Eslam,Shiv Kumar Sarin,Vincent Wai-Sun Wong,Jian-Gao Fan,Takumi Kawaguchi,Sang Hoon Ahn,Ming-Hua Zheng,Gamal Shiha,Yusuf Yilmaz,Rino Alvani Gani,Shahinul Alam,Yock Young Dan,Jia-Horng Kao,Saeed Hamid,Ian Homer Y. Cua,Wah-Kheong Chan,Diana A. Payawal,Soek Siam Tan,Tawesak Tanwandee,Leon A. Adams,Manoj Kumar,Masao Omata,Jacob George +22 more
TL;DR: The clinical practice guidelines of the Asian Pacific Association for the Study of the Liver on MAFLD are presented to improve patient care and awareness of the disease and assist stakeholders in the decision-making process by providing evidence-based data.
Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease
David E. Kleiner,Elizabeth M. Brunt,Laura Wilson,Cynthia Behling,Cynthia D. Guy,Melissa J. Contos,Oscar W. Cummings,Matthew M. Yeh,Ryan M. Gill,Naga Chalasani,Brent A. Neuschwander-Tetri,Anna Mae Diehl,Srinivasan Dasarathy,Norah A. Terrault,Kris V. Kowdley,Rohit Loomba,Patricia Belt,James Tonascia,Joel E. Lavine,Arun J. Sanyal +19 more
TL;DR: In this article, the authors evaluated the histologic evolution of NAFLD and the factors associated with changes in disease severity over time using a prospective cohort substudy from the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) database.
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Sexual Dimorphism of NAFLD in Adults. Focus on Clinical Aspects and Implications for Practice and Translational Research.
Amedeo Lonardo,Ayako Suzuki +1 more
TL;DR: The most prominent sex differences and gaps in NAFLD in humans are discussed, with emphasis on those aspects which are relevant for clinical practice and translational research.
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Liver Fibrosis in Non-alcoholic Fatty Liver Disease: From Liver Biopsy to Non-invasive Biomarkers in Diagnosis and Treatment
Leen J. M. Heyens,Leen J. M. Heyens,Dana Busschots,Dana Busschots,Ger H. Koek,Ger H. Koek,Geert Robaeys,Geert Robaeys,Sven Francque +8 more
TL;DR: A review of the pathogenic mechanisms of the evolution from isolated steatosis to fibrosis is presented in this paper, which serves as the basis for the subsequent discussion of the current and future diagnostic biomarkers and anti-fibrotic drugs.
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A randomised, double-blind, placebo-controlled, multi-centre, dose-range, proof-of-concept, 24-week treatment study of lanifibranor in adult subjects with non-alcoholic steatohepatitis: Design of the NATIVE study.
Francque Sven M,Bedossa Pierre,Abdelmalek Manal F,Anstee Quentin M,Bugianesi Elisabetta,Ratziu Vlad,Huot-Marchand Philippe,Scherrer Bruno,Junien Jean-Louis,Broqua Pierre,Abitbol Jean-Louis +10 more
TL;DR: The primary efficacy endpoint is a 2-point reduction in the activity part of the Steatosis Activity Fibrosis (SAF) histological score (combining inflammation and ballooning) without worsening of fibrosis.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation.
TL;DR: A unified working diagnostic tool for the metabolic syndrome that is convenient to use in clinical practice and that can be used world-wide so that data from different countries can be compared.
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Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.
Christi A. Matteoni,Zobair M. Younossi,Terry Gramlich,Navdeep Boparai,Yao Chang Liu,Arthur J. McCullough +5 more
TL;DR: The outcome of cirrhosis and liver-related death is not uniform across the spectrum of nonalcoholic fatty liver, and poor outcomes are more frequent in patients in whom biopsies show ballooning degeneration and Mallory hyaline or fibrosis.
Journal ArticleDOI
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
Giulio Marchesini,Christopher P. Day,Jean-François Dufour,Ali Canbay,Valerio Nobili,Vlad Ratziu,Herbert Tilg,Michael Roden,Amalia Gastaldelli,Hannele Yki-Järvinen,Fritz Schick,Roberto Vettor,Gema Frühbeck,Lisbeth Mathus-Vliegen +13 more
TL;DR: The final purpose is to improve patient care and awareness of the importance of NAFLD, and to assist stakeholders in the decision-making process by providing evidence-based data, which also takes into consideration the burden of clinical management for the healthcare system.