Complement in the Brain
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TLDR
Interestingly, recent animal studies have also indicated that complement activation products are involved in brain development and synapse formation, which may give insights into the role of complement in processes of neurodegeneration and neuroprotection in the injured or aged and diseased adult central nervous system, and thus aid in identifying novel and specific targets for therapeutic intervention.About:
This article is published in Molecular Immunology.The article was published on 2011-08-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Complement receptor & Classical complement pathway.read more
Citations
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The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1
Leonid P. Shutov,Charles A. Warwick,Xiaoyu Shi,Aswini Gnanasekaran,Andrew J. Shepherd,Durga P. Mohapatra,Trent M. Woodruff,J. David Clark,Yuriy M. Usachev +8 more
TL;DR: This study provides mechanistic insight into how the complement system, a key component of innate immunity, regulates the development of pain hypersensitivity and identifies C5a, NGF, and TRPV1 as key players in this cross-cellular communication.
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Microglia communication: Parallels between aging and Alzheimer's disease.
TL;DR: Pro‐inflammatory drivers of microglia transformation in aging and AD are discussed by focusing on the immune‐modulatory functions of secreted factors, such as cytokines, complement factors and extracellular vesicles.
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Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss.
Michael X. Hernandez,Shan Jiang,Tracy A. Cole,Shu Hui Chu,Maria I. Fonseca,Melody J. Fang,Lindsay A. Hohsfield,Maria D. Torres,Kim N. Green,Rick A. Wetsel,Ali Mortazavi,Andrea J. Tenner +11 more
TL;DR: These results provide links between microglial responses and loss of cognitive performance and, combined with the previous pharmacological approach to inhibit C5aR1 signaling, support the potential of this receptor as a novel therapeutic target for AD in humans.
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Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59.
Hua Zhang,Alan S. Verkman +1 more
TL;DR: The results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.
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Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage.
TL;DR: This review will focus on the balance of complement components and AMPs within the CNS following neonatal HI injury and the effect of that balance on the subsequent brain damage.
References
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Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
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TL;DR: The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.
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Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination.
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TL;DR: At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
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Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.