Complement in the Brain
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TLDR
Interestingly, recent animal studies have also indicated that complement activation products are involved in brain development and synapse formation, which may give insights into the role of complement in processes of neurodegeneration and neuroprotection in the injured or aged and diseased adult central nervous system, and thus aid in identifying novel and specific targets for therapeutic intervention.About:
This article is published in Molecular Immunology.The article was published on 2011-08-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Complement receptor & Classical complement pathway.read more
Citations
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Distinct Patterns of Antiamyloid-β Antibodies in Typical and Atypical Alzheimer Disease
Guillaume Dorothée,Michel Bottlaender,Edmond Moukari,Leonardo Cruz de Souza,Renaud Maroy,Fabian Corlier,Olivier Colliot,Marie Chupin,Foudil Lamari,Stéphane Lehéricy,Bruno Dubois,Marie Sarazin,Pierre Aucouturier +12 more
TL;DR: Serum anti-Aβ IgG1 and IgG3 antibodies differ between distinct forms of AD, and its significance is discussed for possible implications as immune effectors in the specific pathophysiology of AD variants.
Journal ArticleDOI
Complete Factor I Deficiency Due to Dysfunctional Factor I with Recurrent Aseptic Meningo-Encephalitis
Filomeen Haerynck,Patrick Stordeur,Johan VandeWalle,Rudy Van Coster,Victoria Bordon,Frans De Baets,Petra Schelstraete,Cédric Javaux,Marie Rose Bouvry,Véronique Frémeaux-Bacchi,Joke Dehoorne +10 more
TL;DR: A diagnostic work-up of a patient with relapsing inflammatory mediated meningo-encephalitis revealed a rare genetic factor I (FI) deficiency, described for the first time, caused by a defect of FI activity.
Journal ArticleDOI
Complement Has Brains-Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?
Natalia Kunz,Claudia Kemper +1 more
TL;DR: A review of the current state of research regarding complement driven metabolic reprogramming in the context of immune cell tissue entry and residency can be found in this paper, which supports a hypothesis that an evolutionarily conserved cooperation between the complosome, cell metabolism and IFN-γ regulates organismal behavior, as well as immunity.
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Serum levels of proteins involved in amyloid-β clearance are related to cognitive decline and neuroimaging changes in mild cognitive impairment
Shan Liu,Hideaki Suzuki,Hitomi Ito,Tatsumi Korenaga,Hiroyasu Akatsu,Kohji Meno,Kazuhiko Uchida +6 more
TL;DR: This work investigated the utility of Aβ clearance proteins as biomarkers for mild cognitive impairment (MCI) and found them to be useful for damage prevention in Alzheimer's disease.
Journal ArticleDOI
Targeting the complement system in neuromyelitis optica spectrum disorder.
TL;DR: In AQP4-IgG seropositive NMOSD, circulating immunoglobulin G auto-anti... as discussed by the authors is characterized by central nervous system inflammation and demyelination.
References
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Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.