Complement in the Brain
Reads0
Chats0
TLDR
Interestingly, recent animal studies have also indicated that complement activation products are involved in brain development and synapse formation, which may give insights into the role of complement in processes of neurodegeneration and neuroprotection in the injured or aged and diseased adult central nervous system, and thus aid in identifying novel and specific targets for therapeutic intervention.About:
This article is published in Molecular Immunology.The article was published on 2011-08-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Complement receptor & Classical complement pathway.read more
Citations
More filters
Journal ArticleDOI
Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning.
Balazs Gyorffy,Judit Kun,György Török,Éva Bulyáki,Zsolt Borhegyi,Péter Gulyássy,Viktor Kis,Péter Szocsics,András Micsonai,János Matkó,László Drahos,Gábor Juhász,Gábor Juhász,Katalin A. Kékesi,József Kardos +14 more
TL;DR: The results unveiled that C1q label-based synaptic pruning is triggered by and directly linked to apoptotic-like processes in the synaptic compartment, which was confirmed experimentally with apoptosis markers.
Journal ArticleDOI
Protective and Pathological Immunity during Central Nervous System Infections
TL;DR: The focus of this review is to consider the host-pathogen interactions that influence neurotropic infections and to highlight advances in the understanding of innate and adaptive mechanisms of resistance as key determinants of the outcome of CNS infection.
Book ChapterDOI
Progress and Trends in Complement Therapeutics
Daniel Ricklin,John D. Lambris +1 more
TL;DR: This chapter highlights the key changes in the field that shape the current perception of complement-targeted drugs and provides a brief overview of recent strategies and emerging trends.
Journal ArticleDOI
Complement activation in the injured central nervous system: another dual-edged sword?
TL;DR: Recent findings on complement activation and acquired brain or spinal cord injury, i.e. ischaemic-reperfusion injury or stroke, traumatic brain injury (TBI) and spinal Cord injury (SCI), are summarized, highlighting the potential for complement-targeted therapeutics to alleviate the devastating consequences of these neurological conditions.
Journal ArticleDOI
Intersection of pathological tau and microglia at the synapse
TL;DR: The role of microglia in the pathobiology of tauopathies and the mechanism of action of potential therapeutics targeting the immune system in tAUopathies are described.
References
More filters
Journal ArticleDOI
The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
Journal ArticleDOI
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.
Journal ArticleDOI
Structure and function of the blood–brain barrier
TL;DR: The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.
Journal ArticleDOI
Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination.
Claudia F. Lucchinetti,Wolfgang Brück,Joseph E. Parisi,Bernd W. Scheithauer,Moses Rodriguez,Hans Lassmann +5 more
TL;DR: At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
Journal ArticleDOI
Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.