Complement in the Brain
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TLDR
Interestingly, recent animal studies have also indicated that complement activation products are involved in brain development and synapse formation, which may give insights into the role of complement in processes of neurodegeneration and neuroprotection in the injured or aged and diseased adult central nervous system, and thus aid in identifying novel and specific targets for therapeutic intervention.About:
This article is published in Molecular Immunology.The article was published on 2011-08-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Complement receptor & Classical complement pathway.read more
Citations
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C1q as a Regulator of Brain Development: Implications for Autism Spectrum Disorders
TL;DR: In this article, a review summarizes and critically analyzes the evidence of a role for the complement system in the pathogenesis of autism spectrum disorders, concluding that aberrant complement system activity during critical windows of brain development may not only affect the local immune response but lead to atypical brain development.
Neuroinfl ammation in Alzheimer's disease
M. T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +36 more
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Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59
Wioleta M. Zelek,Lewis M. Watkins,Owain W. Howell,Rhian Evans,Sam Loveless,Neil Robertson,Marijke Beenes,Loek Willems,Ricardo Brandwijk,B. Paul Morgan +9 more
TL;DR: CSF levels of sCD59 are not a biomarker of demyelinating diseases, and high levels in CSF relative to plasma suggest an intrathecal source; CD59 expression in brain parenchyma was low, but expression was strong on choroid plexus (CP) epithelium, immediately adjacent the CSF, suggesting that this is the likely source.
Journal ArticleDOI
High levels of serum mannose-binding lectins are associated with the severity and clinical outcomes of severe traumatic brain injury.
TL;DR: Increased serum level of MBL was independently associated with head trauma severity and long-term clinical outcomes of STBI and emerged as an independent predictor for 6-month mortality and unfavorable outcome.
Journal ArticleDOI
Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies.
TL;DR: A review of transcriptome-wide expression profiling of the changes occurring as retinal ganglion cells (RGCs) are lost across different glaucoma models is presented in this paper.
References
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Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.