Complement in the Brain
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TLDR
Interestingly, recent animal studies have also indicated that complement activation products are involved in brain development and synapse formation, which may give insights into the role of complement in processes of neurodegeneration and neuroprotection in the injured or aged and diseased adult central nervous system, and thus aid in identifying novel and specific targets for therapeutic intervention.About:
This article is published in Molecular Immunology.The article was published on 2011-08-01 and is currently open access. It has received 354 citations till now. The article focuses on the topics: Complement receptor & Classical complement pathway.read more
Citations
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Seeking a New Paradigm for Alzheimer's Disease: Considering the Roles of Inflammation, Blood-Brain Barrier Dysfunction, and Prion Disease.
Mark E. McCaulley,Kira A. Grush +1 more
TL;DR: The contribution of inflammation, malfunction of the neurovascular unit, and prion disease to Alzheimer's disease manifestations are reviewed and any or all are candidates for inclusion into a more accurate, inclusive, and useful new paradigm.
Journal ArticleDOI
Complement Activation in the Central Nervous System: A Biophysical Model for Immune Dysregulation in the Disease State.
Nicholas Peoples,Candace Strang +1 more
TL;DR: In this article, the authors explore the mechanics of molecular neuro-immune relationships for the regulatory proteins: Complement Receptor 1, C1-Inhibitor, Factor H, and the CUB-sushi multiple domain family.
Posted ContentDOI
A landscape of the genetic and cellular heterogeneity in Alzheimer disease
Logan Brase,Shih-Feng You,Jorge L Del-Aguila,Yaoyi Dai,Brenna C Novotny,Carolina Sariano-Tarraga,Taitea Dykstra,Maria Victoria Fernandez,John P. Budde,Kristy Bergmann,John C. Morris,Randall J. Bateman,Eric McDade,Chengjie Xiong,Alison Goate,Martin R. Farlow,Jasmeer P. Chhatwal,Peter R. Schofield,Helena C. Chui,Greg T. Sutherland,Jonathan Kipnis,Celeste M. Karch,Bruno A. Benitez,Carlos Cruchaga,Oscar Harari +24 more
TL;DR: In this paper, the authors applied a genetic-based approach to sample selection; their cohort included carriers of AD pathogenic mutations (APP, PSEN1), risk variants in TREM2, and the resilience variant (rs1582763) in the MS4A cluster associated with cerebrospinal fluid (CSF) soluble TREM 2 levels.
Journal ArticleDOI
Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin.
TL;DR: These findings on GPI-MT2 provide a mechanistic link between GPI anchor biosynthesis and protein trafficking in Drosophila and shed light on a novel mechanism for inherited retinal degeneration.
Journal ArticleDOI
Discovery of Small Molecules for Fluorescent Detection of Complement Activation Product C3d
Ronald D. Gorham,Ronald D. Gorham,Vicente Nuñez,Jung-Hsin Lin,Jung-Hsin Lin,Suzan H.M. Rooijakkers,Valentine I. Vullev,Dimitrios Morikis +7 more
TL;DR: This work employed a virtual high-throughput screening protocol to identify molecules with predicted binding to complement C3d and with intrinsic fluorescence properties to enable detection and serves as a foundation for identifying additional fluorescent molecules with high-affinity for C3D that will be explored as noninvasive in vivo diagnostics of complement-mediated inflammation.
References
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Complement: a key system for immune surveillance and homeostasis
TL;DR: An updated view of the function, structure and dynamics of the complement network is described, its interconnection with immunity at large and with other endogenous pathways is highlighted, and its multiple roles in homeostasis and disease are illustrated.