Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study
Massimo Sartelli,Fausto Catena,Luca Ansaloni,Federico Coccolini,Davide Corbella,Ernest E. Moore,Mark A. Malangoni,George C. Velmahos,Raul Coimbra,Kaoru Koike,Ari Leppäniemi,Walter L. Biffl,Zsolt J. Balogh,Cino Bendinelli,Sanjay Gupta,Yoram Kluger,Ferdinando Agresta,Salomone Di Saverio,Gregorio Tugnoli,Elio Jovine,Carlos A. Ordoñez,James Whelan,Gustavo Pereira Fraga,Carlos Augusto Gomes,Gerson Alves Pereira,Kuo-Ching Yuan,Miklosh Bala,Miroslav P. Peev,Offir Ben-Ishay,Yunfeng Cui,Sanjay Marwah,Sanoop K. Zachariah,Imtiaz Wani,Muthukumaran Rangarajan,Boris Sakakushev,Victor Y. Kong,Adamu Ahmed,Ashraf Abbas,Ricardo Alessandro Teixeira Gonsaga,Gianluca Guercioni,Nereo Vettoretto,Elia Poiasina,Rafael Díaz-Nieto,Damien Massalou,Matej Skrovina,Ihor Gerych,Goran Augustin,Jakub Kenig,Vladimir Khokha,Cristian Tranà,Kenneth Y.Y. Kok,Alain Chichom Mefire,Jae Gil Lee,Suk-Kyung Hong,Helmut Alfredo Segovia Lohse,Wagih Ghnnam,Alfredo Verni,Varut Lohsiriwat,Boonying Siribumrungwong,Tamer El Zalabany,Alberto Tavares,Gian Luca Baiocchi,Koray Das,Julien Jarry,Maurice Zida,Norio Sato,Kiyoshi Murata,Tomohisa Shoko,Takayuki Irahara,Ahmed O. Hamedelneel,Noel Naidoo,Abdul Rashid K. Adesunkanmi,Yoshiro Kobe,Wataru Ishii,Kazuyuki Oka,Yoshimitsu Izawa,Hytham K.S. Hamid,Iqbal Khan,AK Attri,Rajeev Sharma,Juan Sanjuan,Marisol Badiel,Rita Barnabé +82 more
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The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013).Abstract:
The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).read more
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Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection
Robert G. Sawyer,Jeffrey A. Claridge,Avery B. Nathens,Ori D. Rotstein,Therese M. Duane,Heather L. Evans,Charles H. Cook,Patrick J. O'Neill,John E. Mazuski,Reza Askari,Mark A. Wilson,Lena M. Napolitano,Nicholas Namias,Preston R. Miller,E. Patchen Dellinger,Christopher M. Watson,Raul Coimbra,Daniel L. Dent,Stephen F. Lowry,Christine S. Cocanour,Michael West,Kaysie L. Banton,William G. Cheadle,Pamela A. Lipsett,Christopher A. Guidry,Kimberley A. Popovsky +25 more
TL;DR: In patients with intraabdominal infections who had undergone an adequate source-control procedure, the outcomes after fixed-duration antibiotic therapy were similar to those after a longer course of antibiotics that extended until after the resolution of physiological abnormalities.
Journal ArticleDOI
Ceftolozane/Tazobactam Plus Metronidazole for Complicated Intra-abdominal Infections in an Era of Multidrug Resistance: Results From a Randomized, Double-Blind, Phase 3 Trial (ASPECT-cIAI)
Joseph S. Solomkin,Ellie Hershberger,Benjamin Miller,Myra Popejoy,Ian Friedland,Judith N. Steenbergen,Minjung Yoon,Sylva H. Collins,Guojun Yuan,Philip S. Barie,Christian Eckmann +10 more
TL;DR: This phase 3 trial compared ceftolozane/tazobactam plus metronidazole vs meropenem for the treatment of complicated intra-abdominal infections with high rates of presumed microbiological eradication of Enterobacteriaceae and Pseudomonas aeruginosa.
Journal ArticleDOI
Efficacy and Safety of Ceftazidime-Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-abdominal Infection: Results From a Randomized, Controlled, Double-Blind, Phase 3 Program
John E. Mazuski,Leanne B. Gasink,Jon Armstrong,Helen Broadhurst,Greg Stone,Douglas R. Rank,Lily Llorens,Paul Newell,Jan Pachl +8 more
TL;DR: In this randomized phase 3 trial, ceftazidime-avibactam plus metronidazole was noninferior to meropenem in treating complicated intra-abdominal infection and with similar efficacy against ceftazerime-resistant and ceftZidime -resistant pathogens and no new safety concerns observed.
Journal ArticleDOI
The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections
Massimo Sartelli,Alain Chichom-Mefire,Francesco M. Labricciosa,Timothy Craig Hardcastle,Fikri M. Abu-Zidan,A R K Adesunkanmi,Luca Ansaloni,Miklosh Bala,Zsolt J. Balogh,Marcelo A. Beltrán,Offir Ben-Ishay,Walter L. Biffl,Arianna Birindelli,Miguel Caínzos,Gianbattista Catalini,Marco Ceresoli,Asri Che Jusoh,Osvaldo Chiara,Federico Coccolini,Raul Coimbra,Francesco Cortese,Zaza Demetrashvili,Salomone Di Saverio,Jose J. Diaz,Valery N. Egiev,Paula Ferrada,Gustavo Pereira Fraga,Wagih Ghnnam,Jae Gil Lee,Carlos Augusto Gomes,Andreas Hecker,Torsten Herzog,Jae Il Kim,Kenji Inaba,Arda Isik,Aleksandar Karamarkovic,Jeffry L. Kashuk,Vladimir Khokha,Andrew W. Kirkpatrick,Yoram Kluger,Kaoru Koike,Victor Y. Kong,Ari Leppäniemi,Gustavo M. Machain,Ronald V. Maier,Sanjay Marwah,Michael McFarlane,Giulia Montori,Ernest E. Moore,Ionut Negoi,Iyiade Olaoye,Abdelkarim H. Omari,Carlos A. Ordoñez,Bruno M. Pereira,Gerson Alves Pereira Júnior,Guntars Pupelis,Tarcisio Reis,Boris Sakakhushev,Norio Sato,Helmut Alfredo Segovia Lohse,Vishal G Shelat,Kjetil Søreide,Kjetil Søreide,Waldemar Uhl,Jan Ulrych,Harry van Goor,George C. Velmahos,Kuo Ching Yuan,Imtiaz Wani,Dieter G. Weber,Sanoop K. Zachariah,Fausto Catena +71 more
TL;DR: The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.
Journal ArticleDOI
Wses Jerusalem Guidelines For Diagnosis And Treatment Of Acute Appendicitis
Salomone Di Saverio,Arianna Birindelli,M. D. Kelly,Fausto Catena,Dieter G. Weber,Massimo Sartelli,Michael Sugrue,Mark De Moya,Carlos Augusto Gomes,Aneel Bhangu,Ferdinando Agresta,Ernest E. Moore,Kjetil Søreide,Ewen A. Griffiths,Steve De Castro,Jeffry L. Kashuk,Yoram Kluger,Ari Leppäniemi,Luca Ansaloni,Manne Andersson,Federico Coccolini,Raul Coimbra,Kurinchi Selvan Gurusamy,Fabio Cesare Campanile,Walter L. Biffl,Osvaldo Chiara,Frederick A. Moore,Andrew B. Peitzman,Gustavo Pereira Fraga,David W da Costa,Ronald V. Maier,Sandro Rizoli,Zsolt J. Balogh,Cino Bendinelli,Roberto Cirocchi,Valeria Tonini,Alice Piccinini,Gregorio Tugnoli,Elio Jovine,Roberto Persiani,Antonio Biondi,Thomas M. Scalea,Philip F. Stahel,Rao R. Ivatury,George C. Velmahos,Roland Andersson +45 more
TL;DR: The current paper is reporting the definitive Guidelines Statements on each of the following topics: Diagnostic efficiency of clinical scoring systems, Role of Imaging, non-operative treatment for uncomplicated appendicitis, timing of appendectomy and in-hospital delay, and Surgical treatment.
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