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Open AccessJournal ArticleDOI

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

Leonidas Chouliaras, +11 more
- 01 Sep 2013 - 
- Vol. 34, Iss: 9, pp 2091-2099
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.
About: 
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.

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Journal ArticleDOI

Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer's Disease.

Michalina Wezyk, +17 more
- 04 Apr 2018 - 
TL;DR: It is shown that the aging-correlated hypermethylation of KLF14 and TRIM59 genes associates with abnormalities in DNA repair and cell cycle control in fEOAD and reinforces the view that the genetic methylation status in the blood may be a valuable predictor of molecular processes occurring in affected tissues.
Journal ArticleDOI

Epigenetic Modulation on Tau Phosphorylation in Alzheimer's Disease.

Chao-Chao Yu, +5 more
- 10 Apr 2019 - 
TL;DR: This review summarizes the current research progress on the mechanisms of epigenetic modification associated with tau phosphorylation and can directly or indirectly affect the regulation of tauosphorylation, thereby participating in AD development and progression.

Transgenerational latent early-life associated regulation unites environment and genetics across generations

Debomoy K. Lahiri, +6 more
TL;DR: This work proposes that this process can occur across generations via transgenerational LEARn (tLEARn), a model that unites environmental exposures and gene expression while providing a mechanistic underpinning for later-occurring disorders.
Journal ArticleDOI

Epigenetics: Recent Advances and Its Role in the Treatment of Alzheimer's Disease.

Xuewen Xiao, +2 more
- 15 Oct 2020 - 
TL;DR: Epigenetics is associated with the pathogenesis of AD, including DNA methylation/hydroxymethylation, histone modifications, and non-coding RNAs, which provide potential therapeutic strategies for AD.
Journal ArticleDOI

Elucidating novel dysfunctional pathways in Alzheimer's disease by integrating loci identified in genetic and epigenetic studies

Adam Smith, +4 more
- 01 Jun 2016 - 
TL;DR: This review focuses on identifying overlapping pathways between published genome- wide association studies and epigenome-wide association studies, highlighting dysfunctional synaptic, lipid metabolism, plasma membrane/cytoskeleton, mitochondrial, and immune cell activation pathways.
References
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Journal ArticleDOI

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Rudolf Jaenisch, +1 more
- 01 Mar 2003 - 
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Mamta Tahiliani, +10 more
- 15 May 2009 - 
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI

Alzheimer's Disease Is a Synaptic Failure

Dennis J. Selkoe
- 25 Oct 2002 - 
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Skirmantas Kriaucionis, +1 more
- 15 May 2009 - 
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI

Linking DNA methylation and histone modification: patterns and paradigms

Howard Cedar, +1 more
- 01 May 2009 - 
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

Philip L. De Jager, +28 more
- 01 Sep 2014 - 

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Skirmantas Kriaucionis, +1 more
- 15 May 2009 - 

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Katie Lunnon, +20 more
- 01 Sep 2014 - 

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

Sun Chong Wang, +2 more
- 16 Jul 2008 - 

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Mamta Tahiliani, +10 more
- 15 May 2009 -