Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
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Immunological evaluation of patients with Alzheimer's disease based on mitogen-stimulated cytokine productions and mitochondrial DNA indicators
TL;DR: In this article , the responsiveness of peripheral blood mononuclear cells (PBMCs) to mitogen Lipopolysaccharides (LPS) and Phytohemagglutinin (PHA), genomic methylation and hydroxymethylation levels, nuclear DNA and mitochondrial DNA damage, respiratory chain enzyme activities, and circulating cell-free mitochondrial DNA levels were detected in 90 patients with Alzheimer's disease.
Dissertation
A study of the polycomb group complexes in the maintenance of heterochromatic genome stability and Alzheimer's disease
TL;DR: In FRENCH and in this paper, the authors proposed a method to solve the problem of the French-English language gap, i.e., the "problem of the difference between
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Brain region-specific genome-wide deoxyribonucleic acid methylation analysis in patients with Alzheimer’s disease
TL;DR: In this paper , a comprehensive deoxyribonucleic acid methylation (DNAm)-transcriptome profile association analysis was conducted to establish whole-genome DNAm profiles and explore DNAm-related genes and their potential functions.
Dissertation
Assesment of Caregiver Experiences and Their Influence on Global DNA Methylation within the Adolescent Hippocampus and Amygdala
TL;DR: The Roth Lab has been one of the most influential and exceptional mentors I have ever had, and I will always be incredibly grateful to Dr. Roth for enabling me to have such significant experiences as mentioned in this paper.
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DNA Methylation as a Biomarker for Monitoring Disease Outcome in Patients with Hypovitaminosis and Neurological Disorders
Olaia Martínez-Iglesias,Vinogran Naidoo,Lola Corzo,Rocío Pego,S Seoane,Susana Rodríguez,M. Alcaraz,Adriana Muniz,Natalia Cacabelos,Ramón Cacabelos +9 more
TL;DR: In this paper , differences in global DNA methylation (5mC) levels in serum samples from patients during the initial-and the follow-up visits were examined, revealing that 5mC has a diagnostic value as a biomarker across different pathologies.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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