Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
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A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease
TL;DR: The current work collected and discussed the mechanisms of PM2.5-induced CNS damage and PM2-induced neurodegenerative diseases are discussed.
Symposium: B rain B ank Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program
Thomas G. Beach,Charles H. Adler,Lucia I. Sue,Geidy E. Serrano,Holly A. Shill,Douglas G. Walker,Lih-Fen Lue,Alex E. Roher,Brittany N. Dugger,Chera L. Maarouf,Alex C. Birdsill,Anthony Intorcia,Megan Saxon-LaBelle,Joel Pullen,Alexander Scroggins,Jessica Filon,Sarah Scott,Brittany Hoffman,Angelica Garcia,John N. Caviness,Joseph G. Hentz,Erika M Driver-Dunckley,Sandra A. Jacobson,Kathryn J. Davis,Christine Belden,Kathy E. Long,Michael Malek-Ahmadi,Jessica Powell,Lisa D. Gale,Lisa R. Nicholson,Richard J. Caselli,Bryan K. Woodruff,Steven Z. Rapscak,Geoffrey L. Ahern,Jiong Shi,Anna D. Burke,Eric M. Reiman,Marwan N. Sabbagh +37 more
TL;DR: The Brain and Body Donation Program at Banner Sun Health Research Institute started in 1987 with brain‐only donations and currently has banked more than 1600 brains, which has contributed to more than 350 publications and more than 200 grant‐funded projects.
Journal ArticleDOI
Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease
Corey T. Watson,Panos Roussos,Panos Roussos,Paras Garg,Daniel Ho,Nidha Azam,Pavel Katsel,Vahram Haroutunian,Vahram Haroutunian,Andrew J. Sharp +9 more
TL;DR: In this paper, the authors performed a genome-wide screen of DNA methylation using the Illumina Infinium HumanMethylation450 platform on bulk tissue samples from the superior temporal gyrus of patients with Alzheimer's disease and non-demented controls.
Journal ArticleDOI
DNA methylation, a hand behind neurodegenerative diseases.
TL;DR: The studies of these four major neurodegenerative diseases conclude the strong suggestion of the important role DNA methylation plays in these diseases, however, each of these diseases has not yet been understood completely as details in some areas remain unclear.
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New Insights into 5hmC DNA Modification: Generation, Distribution and Function.
TL;DR: Recent advances on the generation, distribution, and function of 5hmC modification in mammals are reviewed and its potential roles in plants are discussed.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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