Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
Citations
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Journal ArticleDOI
Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer’s Disease
Bhanu Chandra Karisetty,Akanksha Bhatnagar,Ellen M. Armour,Mariah Beaver,Haolin Zhang,Felice Elefant +5 more
TL;DR: The current understanding of beneficial and detrimental roles for Aβ in synaptic function and epigenetic gene control is discussed and the future promising prospects of early therapeutic interventions aimed at mediating Aβ induced neuroepigenetic and synaptic dysfunctions to delay AD onset are discussed.
Journal ArticleDOI
Genomics in Neurological Disorders
Guangchun Han,Jiya Sun,Jiya Sun,Jiajia Wang,Jiajia Wang,Zhouxian Bai,Zhouxian Bai,Fuhai Song,Fuhai Song,Hongxing Lei +9 more
TL;DR: In this review, recent progresses in the discovery of novel risk genes, treatment targets and peripheral biomarkers employing genomic technologies will be discussed, with a major focus on Alzheimer's disease and autism spectrum disorder.
Journal ArticleDOI
New hope: the emerging role of 5-hydroxymethylcytosine in mental health and disease.
TL;DR: Several putative functions of 5hmC are discussed in the context of its promising clinical relevance and genome-wide disruptions of 5-hydroxymethylcytosine were associated with the development of early and late onset mental illnesses such as autism and Alzheimer's disease.
Journal ArticleDOI
The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.
Vivian Chen,Malik Moncalvo,Dominic Tringali,Lidia Tagliafierro,Ahila Shriskanda,Ekaterina Ilich,Wendy Dong,Boris Kantor,Ornit Chiba-Falek +8 more
TL;DR: For the first time, it is proposed that α-syn interacts with RAN and normally functions in the nucleocytoplasmic transport while exerts its pathogenic effect by sequestering RAN, and it is suggested that defects in the nucleus transport components may be a general pathomechanistic driver of neurodegenerative diseases.
Journal ArticleDOI
Elevated Global DNA Methylation Is Not Exclusive to Amyotrophic Lateral Sclerosis and Is Also Observed in Spinocerebellar Ataxia Types 1 and 2.
Hamid Hamzeiy,Doruk Savaş,Ceren Tunca,Nesli-Ece Sen,Aslı Gündoğdu Eken,Irmak Şahbaz,Daniela Calini,Cinzia Tiloca,Nicola Ticozzi,Antonia Ratti,Vincenzo Silani,A. Nazli Basak +11 more
TL;DR: The results point towards a role for epigenetics modification in ALS, SCA1, and SCA2, and help conclude a dispute on the global 5-mC levels in sALS blood.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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