Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
Citations
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Journal ArticleDOI
Epigenomics of Alzheimer's disease
David A. Bennett,Lei Yu,Jingyun Yang,Gyan Srivastava,Gyan Srivastava,Gyan Srivastava,Cristin Aubin,Cristin Aubin,Cristin Aubin,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager +11 more
TL;DR: Descriptive data is presented to help inform other researchers what to expect from these approaches to better design and power their studies and discuss future directions to inform on the epigenomic architecture of AD.
Journal ArticleDOI
Nanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health
Bozena Smolkova,Naouale El Yamani,Naouale El Yamani,Andrew Collins,Arno C. Gutleb,Maria Dusinska +5 more
TL;DR: Recent advances in the understanding of epigenetic pathological effects of NPs are reviewed, and their possible health impact is discussed with the aim of avoiding potential health risks posed by the use of nanomaterials in foods and food-packaging.
Journal ArticleDOI
Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain
Daniel Condliffe,Andrew Wong,Claire Troakes,Petroula Proitsi,Yogen Patel,Leonidas Chouliaras,Cathy Fernandes,Jonathan D. Cooper,Simon Lovestone,Leonard C. Schalkwyk,Jonathan Mill,Jonathan Mill,Katie Lunnon +12 more
TL;DR: A significant AD-associated decrease in global 5-hydroxymethylcytosine in entorhinal cortex and cerebellum, and differences in 5-formylcytOSine levels between brain regions are identified, which implicates a role for epigenetic alterations in AD.
Journal ArticleDOI
Current Concepts of Neurodegenerative Mechanisms in Alzheimer’s Disease
TL;DR: This review summarizes the current understanding on neurodegenerative mechanisms that lead to the emergence of the pathology of AD.
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Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial
Hui Chen,Shuai Liu,Lu Ji,Tianfeng Wu,Yong Ji,Yuying Zhou,Miaoyan Zheng,Meilin Zhang,Weili Xu,Guowei Huang +9 more
TL;DR: Folic acid is beneficial in patients with AD and inflammation may play an important role in the interaction between folic acid and AD.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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