scispace - formally typeset
Open AccessJournal ArticleDOI

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

Leonidas Chouliaras, +11 more
- 01 Sep 2013 - 
- Vol. 34, Iss: 9, pp 2091-2099
Reads0
Chats0
TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.
About: 
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.

read more

Citations
More filters
Journal ArticleDOI

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

Philip L. De Jager, +28 more
- 01 Sep 2014 - 
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD given that they were observed in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.
Journal ArticleDOI

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Pei-Pei Liu, +3 more
- 23 Aug 2019 - 
TL;DR: It is proposed that fluoxetine, a selective serotonin reuptake inhibitor, has the potential to treat AD and the combination of hypometabolism and autophagy deficiency is likely to be a causative factor for AD.
Journal ArticleDOI

Homocysteine, B Vitamins, and Cognitive Impairment

A. David Smith, +2 more
- 18 Jul 2016 - 
TL;DR: Trials in high-risk subjects, which have taken into account the baseline B vitamin status, show a slowing of cognitive decline and of atrophy in critical brain regions, results that are consistent with modification of the Alzheimer's disease process.

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Gyan Srivastava, +29 more
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD since (1) they are seen in presymptomatic subjects and (2) six of the validated genes connect to a known AD susceptibility gene network.
Journal ArticleDOI

The epigenetics of aging and neurodegeneration.

Roy Lardenoije, +10 more
- 01 Aug 2015 - 
TL;DR: Current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases are reviewed.
References
More filters
Journal ArticleDOI

S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice.

Andrea Fuso, +7 more
- 01 Jul 2012 - 
TL;DR: It is found that S-adenosylmethionine reduced amyloid production, increased spatial memory in TgCRND8 mice and inhibited the upregulation of B vitamin deficiency-induced PSEN1 and BACE1 expression and Tau phosphorylation in T g CRND8 and wild-type mice.
Journal ArticleDOI

Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency

Andrea Fuso, +5 more
- 01 Feb 2011 - 
TL;DR: It is demonstrated that B vitamin deficiency induces hypomethylation of specific CpG moieties in the 5'-flanking region; S-adenosylmethionine has been supplemented as methyl donor to reverse this effect.
Journal ArticleDOI

Purkinje Cell Synapses Target Physiologically Unique Brainstem Neurons

Chris Sekirnjak, +4 more
- 16 Jul 2003 - 
TL;DR: Targeted intracellular recordings revealed that FTNs fired spontaneously at high rates in brain slices and exhibited dramatic postinhibitory rebound firing after the offset of membrane hyperpolarization, indicating a common role for intrinsic firing mechanisms in cerebellar control of diverse behaviors.
Journal ArticleDOI

Age-related increase in levels of 5-hydroxymethylcytosine in mouse hippocampus is prevented by caloric restriction.

Leonidas Chouliaras, +8 more
- 31 May 2012 - 
TL;DR: The findings indicate that the aging process in mice is connected with changes in epigenetic machinery in the hippocampus and suggest that CR acts by influencing epigenetic regulation.
Journal ArticleDOI

Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease.

Stephen D. Ginsberg, +4 more
- 01 Jan 2012 - 
TL;DR: Single population studies of specific neurons and intrinsic circuits will likely yield informative gene expression profile data that may be subthreshold and/or underrepresented in regional studies with an admixture of cell types.
Related Papers (5)

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

Philip L. De Jager, +28 more
- 01 Sep 2014 - 

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

Skirmantas Kriaucionis, +1 more
- 15 May 2009 - 

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Katie Lunnon, +20 more
- 01 Sep 2014 - 

Age-Specific Epigenetic Drift in Late-Onset Alzheimer's Disease

Sun Chong Wang, +2 more
- 16 Jul 2008 - 

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Mamta Tahiliani, +10 more
- 15 May 2009 -