Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
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Journal ArticleDOI
Redox-based disruption of cellular hormesis and promotion of degenerative pathways: perspectives on ageing processes.
Michele Bevere,Giulia Di Cola,Carmen Santangelo,Elisa Grazioli,Lorenzo Marramiero,Pamela Pignatelli,Danilo Bondi,Simona Mrakic-Sposta +7 more
TL;DR: The present work aims to link the redox and cell-centric theories of chronic processes in human biology, focusing on ageing, with a synthetic overview of cellular redox pathways integrated by the concept of hormesis, which leads to several physiopathological processes.
Book ChapterDOI
The epigenetics of aging
TL;DR: The most complicated and least investigated epigenetic alterations that progress with aging are reversible alterations of chromatin that are heritable, but do not affect underlying DNA sequences and, consequently, permanent genetic information as discussed by the authors .
Book ChapterDOI
Epigenetic Biomarkers in Personalized Medicine
TL;DR: The role of epigenetics is not confined to cancer onset and progression, but is becoming increasingly recognized in most noncancerous human complex diseases, indicating that the analysis of the epigenome could represent one of the most promising approaches to refining diagnosis, predicting prognosis, and choosing the most personalized therapeutic approach in human disease.
Journal ArticleDOI
Simultaneous voltammetric determination of 7-methyl-guanine and 5-methyl-cytosine using a cathodically pre-treated boron-doped diamond electrode.
J. E. Oliveira,Alex P. Araújo,Arthur S. Alves,Maycom W.F. Silva,José A. M. Nascimento,Vagner Bezerra dos Santos,Severino Carlos B. Oliveira +6 more
TL;DR: In this article , a new DP voltammetric method for the simultaneous detection and quantification of biomarkers 7-mGua and 5-mCyt using a red-BDDE is proposed.
Journal ArticleDOI
Association between dietary folate intake and cognitive impairment in older US adults: National Health and Nutrition Examination Survey.
Kai Zhang,Bingjin Li,Zhaoxuan Gu,Zhengyan Hou,Tianzhou Liu,Jiayu Zhao,Mengyuan Ruan,Tianqi zhang,Qin Yu,Xiaoqi Yu,Qianyu Lv +10 more
TL;DR: In this article , the association between folate intake and cognitive function was assessed using a multivariate conditional logistic regression model, and the OR of developing folate was 0.96 (95% CI: 0.44-0.56).
References
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Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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