Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
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Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease.
Stephen A. Semick,Rahul Bharadwaj,Leonardo Collado-Torres,Ran Tao,Joo Heon Shin,Amy Deep-Soboslay,James N. Weiss,Daniel R. Weinberger,Thomas M. Hyde,Joel E. Kleinman,Andrew E. Jaffe,Venkata S. Mattay +11 more
TL;DR: This integrated analysis implicates novel genes in Alzheimer's disease that have gene expression correlates, such as ANKRD30B, and illustrates the value of integrating epigenetic and transcriptomic data for understanding complex disease.
Journal ArticleDOI
Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues.
TL;DR: Findings from the laboratory and others combined with supporting literary evidences on molecular switches of brain aging and their potential as recovery targets are reviewed.
Journal ArticleDOI
Integrated whole transcriptome and DNA methylation analysis identifies gene networks specific to late-onset Alzheimer's disease.
Crystal Humphries,Martin A. Kohli,Lubov Nathanson,Patrice L. Whitehead,Gary W. Beecham,Eden R. Martin,Deborah C. Mash,Margaret A. Pericak-Vance,John R. Gilbert +8 more
TL;DR: Examining transcription in late-onset Alzheimer's disease and comparing it to cognitively normal controls and a cohort of "disease controls" indicates several key processes, genes, and networks specific to the disease.
Journal ArticleDOI
Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
Carlos P. Fitzsimons,Emma J. van Bodegraven,Marijn Schouten,Roy Lardenoije,Konstantinos Kompotis,Gunter Kenis,Mark van den Hurk,Marco P. Boks,Caroline Biojone,Samia R. L. Joca,Harry W.M. Steinbusch,Katie Lunnon,Diego Mastroeni,Jonathan Mill,Paul J. Lucassen,Paul D. Coleman,Daniel L.A. van den Hove,Bart P. F. Rutten,Bart P. F. Rutten +18 more
TL;DR: The epigenetic mechanisms relevant for NSCs and AD etiology are reviewed, and the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, are reviewed.
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The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
TL;DR: An overview of the genomic distribution of 5hmC is provided, and recent findings on the role of this mark and the potential consequences of its misregulation during three fundamental biological processes: cell differentiation, cancer and aging are examined.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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