Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.
Leonidas Chouliaras,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Andrew Grover,Gunter Kenis,Patrick R. Hof,Harry W.M. Steinbusch,Paul D. Coleman,Bart P. F. Rutten,Daniel L.A. van den Hove,Daniel L.A. van den Hove +11 more
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TLDR
Human postmortem results strengthen the notion that AD is associated with alterations in DNA methylation and hydroxymethylation, and provide a basis for further epigenetic studies identifying the exact genetic loci with aberrant epigenetic signatures.About:
This article is published in Neurobiology of Aging.The article was published on 2013-09-01 and is currently open access. It has received 351 citations till now. The article focuses on the topics: DNA Hydroxymethylation & DNA methylation.read more
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Impact of DNMT1 and DNMT3a forebrain knockout on depressive- and anxiety like behavior in mice.
Michael J. Morris,Michael J. Morris,Elisa S. Na,Elisa S. Na,Anita E. Autry,Lisa M. Monteggia +5 more
TL;DR: The data suggest that DNMT1 and DNMT3a are distinctly involved in affective behavior and thatDNMT1 may ultimately represent a potential target for treatment of certain affective behavioral disorders.
Journal ArticleDOI
Epigenetics of Alzheimer's Disease.
Matea Nikolac Perkovic,Alja Videtič Paska,Marcela Konjevod,Katarina Kouter,Dubravka Švob Štrac,Gordana Nedic Erjavec,Nela Pivac +6 more
TL;DR: A brief overview of the current knowledge regarding the role of epigenetics (including mitoepigenetics) in AD, and the possibility of applying these advances for future AD therapy is provided in this article.
Journal ArticleDOI
The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders.
TL;DR: This mini-review covers the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
Journal ArticleDOI
Genome-wide alterations in hippocampal 5-hydroxymethylcytosine links plasticity genes to acute stress
Sisi Li,Ligia A. Papale,Qi Zhang,Andy Madrid,Li Chen,Pankaj Chopra,Sunduz Keles,Peng Jin,Reid S. Alisch +8 more
TL;DR: Combining an established chemical labeling and affinity purification method coupled with high-throughput sequencing technology to generate the first genome-wide profile of hippocampal 5hmC following exposure to acute restraint stress and a one-hour recovery reveals an environmental impact on this newly discovered epigenetic mark in the brain.
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Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease
Liqi Shu,Wenjia Sun,Liping Li,Liping Li,Zihui Xu,Li Lin,Pei Xie,Pei Xie,Hui Shen,Hui Shen,Luoxiu Huang,Qi Xu,Peng Jin,Xuekun Li,Xuekun Li +14 more
TL;DR: It is shown that amyloid peptide 1–42 (Aβ1-42) could significantly reduce the overall level of 5hmC in vitro, and5hmC-mediated epigenetic regulation could potentially be involved in the pathogenesis of AD.
References
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Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
Journal ArticleDOI
Alzheimer's Disease Is a Synaptic Failure
TL;DR: Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Journal ArticleDOI
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
TL;DR: It is shown that, as well as 5mC in mammalian genomes, there are also significant amounts of 5-hydroxymethylcytosine (5hmC) in DNA of Purkinje neurons, which have large nuclei with apparently very little heterochromatin.
Journal ArticleDOI
Linking DNA methylation and histone modification: patterns and paradigms
Howard Cedar,Yehudit Bergman +1 more
TL;DR: Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.
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