COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
Behnood Bikdeli,Mahesh V. Madhavan,David Jiménez,Taylor Chuich,Isaac Dreyfus,Elissa Driggin,Caroline Der Nigoghossian,Walter Ageno,Mohammad Madjid,Yutao Guo,Liang V. Tang,Yu Hu,Jay Giri,Mary Cushman,Isabelle Quéré,Evangelos Dimakakos,C. Michael Gibson,C. Michael Gibson,Giuseppe Lippi,Emmanuel J. Favaloro,Jawed Fareed,Joseph A. Caprini,Alfonso Tafur,John R. Burton,Dominic P. Francese,Elizabeth Y. Wang,Anna Falanga,Claire McLintock,Beverley J. Hunt,Alex C. Spyropoulos,Geoffrey D. Barnes,John W. Eikelboom,John W. Eikelboom,Ido Weinberg,Sam Schulman,Marc Carrier,Gregory Piazza,Gregory Piazza,Joshua A. Beckman,P. Gabriel Steg,Gregg W. Stone,Stephan Rosenkranz,Samuel Z. Goldhaber,Samuel Z. Goldhaber,Sahil A. Parikh,Manuel Monreal,Harlan M. Krumholz,Stavros Konstantinides,Jeffrey I. Weitz,Gregory Y.H. Lip,Gregory Y.H. Lip +50 more
TLDR
The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2020-06-16 and is currently open access. It has received 2222 citations till now. The article focuses on the topics: Platelet activation & Antithrombotic.read more
Citations
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Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage: A Meta-Analysis
TL;DR: Use of thrombolytics was associated with lower all-cause mortality, lower risk of recurrent pulmonary embolism, and greater risks of major bleeding in patients 65 years and younger.
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COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management.
Pedro Fraiman,Clécio de Oliveira Godeiro Junior,Elena Moro,Francesco Cavallieri,Marialuisa Zedde +4 more
TL;DR: Cerebrovascular events are relatively common findings in COVID-19 infection, and they could have a multifactorial etiology, and more accurate and prospective data are needed to better understand the impact of cerebrov vascular events in COIDs.
Journal ArticleDOI
Should cyclosporine be useful in renal transplant recipients affected by SARS-CoV-2?
Beatriz Rodríguez-Cubillo,Maria Angeles Moreno de la Higuera,Rafael Lucena,Elena Valdés Franci,Maria Hurtado,Natividad Calvo Romero,Antolina Rodríguez Moreno,Daniela Valencia,Mercedes Velo,Iñigo S Fornie,Ana Sánchez-Fructuoso +10 more
TL;DR: Renal function did not deteriorate and signs of rejection were not observed in any patient on the second treatment regime, suggesting immunosuppressant treatment based on cyclosporine could be safe and effective for KTRs diagnosed with COVID‐19.
Journal ArticleDOI
Urgent reconsideration of lung edema as a preventable outcome in COVID-19: Inhibition of TRPV4 represents a promising and feasible approach
TL;DR: This work argues for inhibition of the transient receptor potential vanilloid 4 (TRPV4) calcium-permeable ion channel as a strategy to address the alveolo-capillary barrier of the lung and argues for expeditious clinical testing of this inhibitor in COVID-19 patients with respiratory malfunction and at risk for lung edema.
Journal ArticleDOI
COVID-19 Vaccines: Should We Fear ADE?
TL;DR: Safe and effective COVID 19 vaccines must avoid VAH, and this outcome is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological or pathological attributes of ADE disease exemplified by the dengue viruses.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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