COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
Behnood Bikdeli,Mahesh V. Madhavan,David Jiménez,Taylor Chuich,Isaac Dreyfus,Elissa Driggin,Caroline Der Nigoghossian,Walter Ageno,Mohammad Madjid,Yutao Guo,Liang V. Tang,Yu Hu,Jay Giri,Mary Cushman,Isabelle Quéré,Evangelos Dimakakos,C. Michael Gibson,C. Michael Gibson,Giuseppe Lippi,Emmanuel J. Favaloro,Jawed Fareed,Joseph A. Caprini,Alfonso Tafur,John R. Burton,Dominic P. Francese,Elizabeth Y. Wang,Anna Falanga,Claire McLintock,Beverley J. Hunt,Alex C. Spyropoulos,Geoffrey D. Barnes,John W. Eikelboom,John W. Eikelboom,Ido Weinberg,Sam Schulman,Marc Carrier,Gregory Piazza,Gregory Piazza,Joshua A. Beckman,P. Gabriel Steg,Gregg W. Stone,Stephan Rosenkranz,Samuel Z. Goldhaber,Samuel Z. Goldhaber,Sahil A. Parikh,Manuel Monreal,Harlan M. Krumholz,Stavros Konstantinides,Jeffrey I. Weitz,Gregory Y.H. Lip,Gregory Y.H. Lip +50 more
TLDR
The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2020-06-16 and is currently open access. It has received 2222 citations till now. The article focuses on the topics: Platelet activation & Antithrombotic.read more
Citations
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Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial.
Alex C. Spyropoulos,Alex C. Spyropoulos,Alex C. Spyropoulos,Mark Goldin,Mark Goldin,Dimitrios Giannis,Wassim Diab,Janice Wang,Janice Wang,Sameer Khanijo,Andrea Mignatti,Andrea Mignatti,Eugenia Gianos,Eugenia Gianos,Marc Cohen,Gulru Sharifova,Jeet Lund,Alfonso Tafur,Alfonso Tafur,Paul A. Lewis,Kevin P. Cohoon,Husneara Rahman,Cristina Sison,Cristina Sison,Martin Lesser,Martin Lesser,Kanta Ochani,Nirav Agrawal,Judith Hsia,Victoria E. Anderson,Marc P. Bonaca,Jonathan L. Halperin,Jeffrey I. Weitz,Hep-Covid Investigators +33 more
TL;DR: In this article, the authors evaluated the effects of therapeutic-dose low-molecular-weight heparin (LMWH) vs institutional standard prophylactic or intermediate-dose heparins for thromboprophylaxis in high-risk hospitalized patients with COVID-19.
Journal ArticleDOI
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.
Sean X. Gu,Tarun Tyagi,Kanika Jain,Vivian W. Gu,Seung-Hee Lee,Jonathan M. Hwa,Jennifer M. Kwan,Diane S. Krause,Alfred Ian Lee,Stephanie Halene,Kathleen A. Martin,Hyung J. Chun,John Hwa +12 more
TL;DR: The latest evidence indicating that platelet and endothelial dysfunction are essential components of CO VID-19 pathology is summarized, the potential mechanisms underlying the contribution of cardiovascular risk factors to the most severe outcomes in COVID-19 are described and the roles of coagulopathy, thrombocytopathy and endotheliopathy are highlighted.
Journal ArticleDOI
American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19.
Adam Cuker,Eric Tseng,Robby Nieuwlaat,Robby Nieuwlaat,Pantep Angchaisuksiri,Clifton Blair,Kathryn Dane,Jennifer Davila,Maria T. DeSancho,David L. Diuguid,Daniel O. Griffin,Susan R. Kahn,Frederikus A. Klok,Alfred Ian Lee,Ignacio Neumann,Ashok Pai,Menaka Pai,Marc Philip Righini,Kristen M. Sanfilippo,Deborah M. Siegal,Mike Skara,Kamshad Touri,Elie A. Akl,Imad Bou Akl,Mary Boulos,Romina Brignardello-Petersen,Rana Charide,Matthew T. V. Chan,Karin Lee Dearness,Andrea Darzi,Andrea Darzi,Philipp Kolb,Luis Enrique Colunga-Lozano,Razan Mansour,Gian Paolo Morgano,Gian Paolo Morgano,Rami Z. Morsi,Atefeh Noori,Thomas Piggott,Yuan Qiu,Yetiani Roldan,Finn Schünemann,Adrienne Stevens,Adrienne Stevens,Karla Solo,Karla Solo,Matthew Ventresca,Matthew Ventresca,Wojtek Wiercioch,Wojtek Wiercioch,Reem A. Mustafa,Holger J. Schünemann +51 more
TL;DR: The evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for thromboprophylaxis for patients with COVID-19-related critical illness and acute illness who do not have confirmed or suspected venous thromboembolism (VTE) as mentioned in this paper.
Journal ArticleDOI
The case of complement activation in COVID-19 multiorgan impact.
TL;DR: The hypothesis that blockade of the terminal complement pathway may represent a potential therapeutic option for the prevention and treatment of lung and multi-organ damage is proposed.
Journal ArticleDOI
Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression.
TL;DR: Cerebrovascular and cardiovascular diseases were associated with increased risk for poor outcome in COVID-19 and meta-regression demonstrated that the association was not influenced by gender, age, hypertension, diabetes, and respiratory comorbidities.
References
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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