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Open AccessJournal ArticleDOI

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

Behnood Bikdeli, +50 more
- 16 Jun 2020 - 
- Vol. 75, Iss: 23, pp 2950-2973
TLDR
The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.
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This article is published in Journal of the American College of Cardiology.The article was published on 2020-06-16 and is currently open access. It has received 2222 citations till now. The article focuses on the topics: Platelet activation & Antithrombotic.

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A narrative review of venous thrombosis epidemiology, pathophysiology, and anticoagulant therapies and trials in severe acute respiratory syndrome coronavirus 2 infection.

TL;DR: The overwhelming inflammatory response in patients with SARS-CoV2 infection leads to a hypercoagulable state, microthrombosis, large vessel thromboses, and ultimately death, and early VTE prophylaxis should be used in all admitted patients.
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COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

TL;DR: Recent studies suggest the beneficial effect of the anticoagulation in severely ill COVID-19 patients, with an important reduction in mortality, opening the door to a new proposal increasing the dose of LMWH in this scenario.
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Practice Modification for Pandemics: A Model for Surge Planning in Obstetrics.

TL;DR: This review highlights proposed pandemic-adjusted modifications in obstetric care with discussion of risks and benefits based on available evidence, and suggests best practices for balancing community-mitigation efforts with appropriate care of obstetric patients.
References
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Journal ArticleDOI

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.

TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI

A pneumonia outbreak associated with a new coronavirus of probable bat origin

TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Journal ArticleDOI

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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