COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
Behnood Bikdeli,Mahesh V. Madhavan,David Jiménez,Taylor Chuich,Isaac Dreyfus,Elissa Driggin,Caroline Der Nigoghossian,Walter Ageno,Mohammad Madjid,Yutao Guo,Liang V. Tang,Yu Hu,Jay Giri,Mary Cushman,Isabelle Quéré,Evangelos Dimakakos,C. Michael Gibson,C. Michael Gibson,Giuseppe Lippi,Emmanuel J. Favaloro,Jawed Fareed,Joseph A. Caprini,Alfonso Tafur,John R. Burton,Dominic P. Francese,Elizabeth Y. Wang,Anna Falanga,Claire McLintock,Beverley J. Hunt,Alex C. Spyropoulos,Geoffrey D. Barnes,John W. Eikelboom,John W. Eikelboom,Ido Weinberg,Sam Schulman,Marc Carrier,Gregory Piazza,Gregory Piazza,Joshua A. Beckman,P. Gabriel Steg,Gregg W. Stone,Stephan Rosenkranz,Samuel Z. Goldhaber,Samuel Z. Goldhaber,Sahil A. Parikh,Manuel Monreal,Harlan M. Krumholz,Stavros Konstantinides,Jeffrey I. Weitz,Gregory Y.H. Lip,Gregory Y.H. Lip +50 more
TLDR
The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2020-06-16 and is currently open access. It has received 2222 citations till now. The article focuses on the topics: Platelet activation & Antithrombotic.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Post-acute COVID-19 syndrome.
Ani Nalbandian,Kartik Sehgal,Kartik Sehgal,Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Claire McGroder,Jacob S. Stevens,Joshua R. Cook,Anna S. Nordvig,Daniel Shalev,Tejasav S. Sehrawat,Neha Ahluwalia,Behnood Bikdeli,Donald Dietz,Caroline Der-Nigoghossian,Nadia Liyanage-Don,Gregg F. Rosner,Elana J. Bernstein,Sumit Mohan,Akinpelumi A Beckley,David S. Seres,Toni K. Choueiri,Toni K. Choueiri,Nir Uriel,John C. Ausiello,Domenico Accili,Daniel E. Freedberg,Matthew R. Baldwin,Allan Schwartz,Daniel Brodie,Christine Kim Garcia,Mitchell S.V. Elkind,Jean M. Connors,Jean M. Connors,John P. Bilezikian,Donald W. Landry,Elaine Wan +37 more
TL;DR: A comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae is provided in this paper, where the authors discuss relevant considerations for the multidisciplinary care of COPD survivors and propose a framework for the identification of those at high risk for COPD and their coordinated management through dedicated COPD clinics.
Journal ArticleDOI
Extrapulmonary manifestations of COVID-19.
Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Kartik Sehgal,Kartik Sehgal,Nandini Nair,Shiwani Mahajan,Tejasav S. Sehrawat,Behnood Bikdeli,Behnood Bikdeli,Neha Ahluwalia,John C. Ausiello,Elaine Wan,Daniel E. Freedberg,Ajay J. Kirtane,Sahil A. Parikh,Mathew S. Maurer,Anna S. Nordvig,Domenico Accili,Joan M. Bathon,Sumit Mohan,Kenneth A. Bauer,Kenneth A. Bauer,Martin B. Leon,Harlan M. Krumholz,Nir Uriel,Mandeep R. Mehra,Mitchell S.V. Elkind,Mitchell S.V. Elkind,Gregg W. Stone,Allan Schwartz,David D. Ho,John P. Bilezikian,Donald W. Landry +33 more
TL;DR: The extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 are reviewed to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
Journal ArticleDOI
COVID-19 and its implications for thrombosis and anticoagulation.
Jean M. Connors,Jerrold H. Levy +1 more
TL;DR: COVID-19–associated coagulopathy should be managed as it would be for any critically ill patient, following the established practice of using thromboembolic prophylaxis for critically ill hospitalized patients, and standard supportive care measures for those with sepsis-induced coagULopathy or DIC.
Journal ArticleDOI
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study.
Dominic Wichmann,Jan-Peter Sperhake,Marc Lütgehetmann,Stefan Steurer,Carolin Edler,Axel Heinemann,Fabian Heinrich,Herbert Mushumba,Inga Kniep,Ann Sophie Schröder,Christoph Burdelski,Geraldine de Heer,Axel Nierhaus,Daniel Frings,Susanne Pfefferle,Heinrich Becker,Hanns Bredereke-Wiedling,Andreas de Weerth,Hans-Richard Paschen,Sara Sheikhzadeh-Eggers,Axel Stang,Stefan Schmiedel,Carsten Bokemeyer,Marylyn M. Addo,Martin Aepfelbacher,Klaus Püschel,Stefan Kluge +26 more
TL;DR: In this paper, the causes of COVID-19-related deaths were investigated in a single academic medical center in the German federal state of Hamburg for patients dying with a polymerase chain reaction-confirmed diagnosis of CoV-19 patients.
References
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Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 Trial: A comparison of fractional flow reserve–guided percutaneous coronary intervention and coronary artery bypass graft surgery in patients with multivessel coronary artery disease
Frederik M. Zimmermann,Bernard De Bruyne,Nico H.J. Pijls,Manisha Desai,Keith G. Oldroyd,Seung-Jung Park,Michael J. Reardon,Olaf Wendler,Joseph Woo,Alan C. Yeung,William F. Fearon +10 more
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Clopidogrel Increases Dasabuvir Exposure With or Without Ritonavir, and Ritonavir Inhibits the Bioactivation of Clopidogrel.
Matti K. Itkonen,Aleksi Tornio,Outi Lapatto-Reiniluoto,Mikko Neuvonen,Pertti J. Neuvonen,Mikko Niemi,Janne T. Backman +6 more
TL;DR: Clopidogrel markedly elevates dasabuvir concentrations, and patients receiving ritonavir are at risk for diminished clopIDogrel response.
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Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites
Niloufar Marsousi,Niloufar Marsousi,Youssef Daali,Youssef Daali,Youssef Daali,Pierre Fontana,Pierre Fontana,Jean-Luc Reny,Jean-Luc Reny,Virginie Ancrenaz-Sirot,Alexandra Calmy,Serge Rudaz,Serge Rudaz,Jules Alexandre Desmeules,Caroline Flora Samer,Caroline Flora Samer +15 more
TL;DR: Prasugrel appears to remain an adequate antiplatelet agent in HIV-infected patients and could be preferred to clopidogrel in this context, regardless of the metabolic interaction and inhibition of its bioactivation pathways.
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Pulmonary embolism response teams: Purpose, evidence for efficacy, and future research directions
TL;DR: The PERT model and purpose is described, the structure and organization are presented, the available evidence for efficacy and usefulness is examined, and future directions for research are proposed to demonstrate the value of PERT and determine if this multidisciplinary approach represents a new standard of care.
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