COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
Behnood Bikdeli,Mahesh V. Madhavan,David Jiménez,Taylor Chuich,Isaac Dreyfus,Elissa Driggin,Caroline Der Nigoghossian,Walter Ageno,Mohammad Madjid,Yutao Guo,Liang V. Tang,Yu Hu,Jay Giri,Mary Cushman,Isabelle Quéré,Evangelos Dimakakos,C. Michael Gibson,C. Michael Gibson,Giuseppe Lippi,Emmanuel J. Favaloro,Jawed Fareed,Joseph A. Caprini,Alfonso Tafur,John R. Burton,Dominic P. Francese,Elizabeth Y. Wang,Anna Falanga,Claire McLintock,Beverley J. Hunt,Alex C. Spyropoulos,Geoffrey D. Barnes,John W. Eikelboom,John W. Eikelboom,Ido Weinberg,Sam Schulman,Marc Carrier,Gregory Piazza,Gregory Piazza,Joshua A. Beckman,P. Gabriel Steg,Gregg W. Stone,Stephan Rosenkranz,Samuel Z. Goldhaber,Samuel Z. Goldhaber,Sahil A. Parikh,Manuel Monreal,Harlan M. Krumholz,Stavros Konstantinides,Jeffrey I. Weitz,Gregory Y.H. Lip,Gregory Y.H. Lip +50 more
TLDR
The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2020-06-16 and is currently open access. It has received 2222 citations till now. The article focuses on the topics: Platelet activation & Antithrombotic.read more
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COVID-19 induces a hyperactive phenotype in circulating platelets
Shane P. Comer,Sarah Cullivan,Paulina B. Szklanna,Luisa Weiss,Steven Cullen,Sarah Kelliher,Albert Smolenski,Niamh Moran,Claire A Murphy,Claire A Murphy,Haidar Altaie,John Curran,Katherine M.A. O'Reilly,Katherine M.A. O'Reilly,Aoife G. Cotter,Aoife G. Cotter,Brian Marsh,Brian Marsh,Sean Gaine,Sean Gaine,Patrick W. G. Mallon,Brian McCullagh,Brian McCullagh,Fionnuala Ní Áinle,Barry Kevane,Barry Kevane,Patricia B. Maguire +26 more
TL;DR: Routine clinical blood parameters including increased MPV and decreased platelet:neutrophil ratio are associated with disease severity in COVID-19 upon hospitalisation and intensive care unit admission and abnormal platelet reactivity may contribute to hypercoagulability in CO VID-19.
Journal ArticleDOI
COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight?
TL;DR: It is hypothesize that overreaction of the renin-angiotensin-aldosterone may account for the myriad of unusual biochemical and clinical abnormalities noted in patients infected with SARS-CoV-2.
Journal ArticleDOI
Increased risk of acute stroke among patients with severe COVID-19: a multicenter study and meta-analysis.
Timo Siepmann,Annahita Sedghi,Erik Simon,Simon Winzer,Jessica Barlinn,Lutz Mirow,Martin Wolz,T. Gruenewald,Percy Schroettner,S. von Bonin,L.-P. Pallesen,Bernhard Rosengarten,Joerg Schubert,T. Lohmann,J. Machetanz,Peter M. Spieth,Thea Koch,Stefan R. Bornstein,Heinz Reichmann,Volker Puetz,Kristian Barlinn +20 more
TL;DR: The risk of acute stroke in patients with severe and non‐severe COVID‐19 is defined and thromboembolic complications possibly mediated by increased blood coagulability and inflammatory endothelial impairment are identified.
Journal ArticleDOI
Prophylactic anticoagulants for people hospitalised with COVID-19
Ronald Lg Flumignan,Jéssica Dantas de Sá Tinôco,Patricia If Pascoal,Libnah Leal Areias,Marcelly Santos Cossi,Maria Icd Fernandes,Isabelle Kf Costa,Larissa Souza,Charbel F Matar,Britta Tendal,Virginia Fm Trevisani,Álvaro Nagib Atallah,Luis Cu Nakano +12 more
TL;DR: The effects of prophylactic anticoagulants versus active comparator, placebo or no intervention, on mortality and the need for respiratory support in people hospitalised with COVID-19 were assessed.
Journal ArticleDOI
Multimodality imaging of COVID-19 pneumonia: from diagnosis to follow-up. A comprehensive review.
Anna Rita Larici,Giuseppe Cicchetti,Riccardo Marano,Riccardo Marano,Biagio Merlino,Lorenzo Elia,Lucio Calandriello,Annemilia del Ciello,Alessandra Farchione,Giancarlo Savino,A Infante,Luigi Larosa,Cesare Colosimo,Riccardo Manfredi,L Natale +14 more
TL;DR: The diagnostic capabilities and limitations of chest X-ray and high-resolution computed tomography in defining the common imaging features of COVID-19 pneumonia and correlating them with the underlying pathogenic mechanisms are understood.
References
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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