COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up
Behnood Bikdeli,Mahesh V. Madhavan,David Jiménez,Taylor Chuich,Isaac Dreyfus,Elissa Driggin,Caroline Der Nigoghossian,Walter Ageno,Mohammad Madjid,Yutao Guo,Liang V. Tang,Yu Hu,Jay Giri,Mary Cushman,Isabelle Quéré,Evangelos Dimakakos,C. Michael Gibson,C. Michael Gibson,Giuseppe Lippi,Emmanuel J. Favaloro,Jawed Fareed,Joseph A. Caprini,Alfonso Tafur,John R. Burton,Dominic P. Francese,Elizabeth Y. Wang,Anna Falanga,Claire McLintock,Beverley J. Hunt,Alex C. Spyropoulos,Geoffrey D. Barnes,John W. Eikelboom,John W. Eikelboom,Ido Weinberg,Sam Schulman,Marc Carrier,Gregory Piazza,Gregory Piazza,Joshua A. Beckman,P. Gabriel Steg,Gregg W. Stone,Stephan Rosenkranz,Samuel Z. Goldhaber,Samuel Z. Goldhaber,Sahil A. Parikh,Manuel Monreal,Harlan M. Krumholz,Stavros Konstantinides,Jeffrey I. Weitz,Gregory Y.H. Lip,Gregory Y.H. Lip +50 more
TLDR
The current understanding of the pathogenesis, epidemiology, management and outcomes of patients with COVID-19 who develop venous or arterial thrombosis, and of those with preexistingThrombotic disease who develop CO VID-19 are reviewed.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2020-06-16 and is currently open access. It has received 2222 citations till now. The article focuses on the topics: Platelet activation & Antithrombotic.read more
Citations
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Red cell bound antibodies and transfusion requirements in hospitalized patients with COVID-19.
Alessandra Berzuini,Cristiana Bianco,Cinzia Paccapelo,Francesco Bertolini,Giuliana Gregato,Alessandra Cattaneo,Elisa Erba,Alessandra Bandera,Alessandra Bandera,Andrea Gori,Andrea Gori,Giuseppe Lamorte,Maria Manunta,Laura Porretti,Nicoletta Revelli,Francesca Truglio,Giacomo Grasselli,Giacomo Grasselli,Alberto Zanella,Alberto Zanella,Stefania Villa,Luca Valenti,Luca Valenti,Daniele Prati +23 more
TL;DR: The observation that nearly half of patients with COVID-19 tested at their blood center had a positive direct antiglobulin test (DAT), however, eluates did not react with any test cells but did react with red cells from other patients withCOVID- 19 that were DAT negative, suggests that CO VID-19 may modulate the red cell membrane and present novel antigenic epitopes.
Journal ArticleDOI
Management of the thrombotic risk associated with COVID-19: guidance for the hemostasis laboratory
Michael Hardy,Thomas Lecompte,Jonathan Douxfils,Sarah Lessire,J. M. Dogne,Bernard Chatelain,Sophie Testa,Isabelle Gouin-Thibault,Yves Gruel,R. L. Medcalf,H. ten Cate,Giuseppe Lippi,François Mullier +12 more
TL;DR: Evaluating the role of hemostasis tests in the management of COVID-19 and discussing their main limitations is discussed.
Journal ArticleDOI
Chest x-ray severity score in COVID-19 patients on emergency department admission: a two-centre study.
Cristian Giuseppe Monaco,Federico Zaottini,Simone Schiaffino,Alessandro Villa,Gianmarco Della Pepa,Luca Alessandro Carbonaro,Laura Menicagli,Andrea Cozzi,Serena Carriero,Francesco Arpaia,Giovanni Di Leo,Davide Astengo,Ilan Rosenberg,Francesco Sardanelli +13 more
TL;DR: Proposed CXR pulmonary severity score in COVID-19 showed moderate to almost perfect interobserver agreement and significant but weak correlations with clinical parameters, potentially furthering CXr integration in patients’ stratification.
Journal ArticleDOI
COVID-19 cardiovascular epidemiology, cellular pathogenesis, clinical manifestations and management.
Yasar Sattar,Waqas Ullah,Hiba Rauf,Hafeez Ul Hassan Virk,Sunita Yadav,Medhat Chowdhury,Michael Connerney,Sahil Mamtani,Mohit Pahuja,Mohit Pahuja,Raj D. Patel,Raj D. Patel,Tanveer Mir,Talal Almas,Homam Moussa Pacha,M. Chadi Alraies +15 more
TL;DR: The cellular pathophysiology, clinical manifestations and treatment modalities of the cardiac manifestations seen in patients with COVID-19 are reviewed.
Journal ArticleDOI
Coagulation dysfunction: A hallmark in COVID-19.
TL;DR: The mechanisms of COVID-19 underlying coagulation activation are discussed and the implications for anticoagulant and thrombolytic treatment in the management of CO VID-19 are discussed, which provide opportunities to prevent or reduce "excessive" thrombin generation, while preserving "adaptive" hemostasis.
References
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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