Journal ArticleDOI
Dynamic Nanoparticle Assemblies for Biomedical Applications
TLDR
The application‐driven design of surface ligands for stimuli‐responsive nanoparticle assemblies that are capable of sensing small changes in the disease microenvironment, which induce the related changes in their physico‐chemical properties are described.Abstract:
Designed synthesis and assembly of nanoparticles assisted by their surface ligands can create “smart” materials with programmed responses to external stimuli for biomedical applications. These assemblies can be designed to respond either exogenously (for example, to magnetic field, temperature, ultrasound, light, or electric pulses) or endogenously (to pH, enzymatic activity, or redox gradients) and play an increasingly important role in a diverse range of biomedical applications, such as biosensors, drug delivery, molecular imaging, and novel theranostic systems. In this review, the recent advances and challenges in the development of stimuli-responsive nanoparticle assemblies are summarized; in particular, the application-driven design of surface ligands for stimuli-responsive nanoparticle assemblies that are capable of sensing small changes in the disease microenvironment, which induce the related changes in their physico-chemical properties, is described. Finally, possible future research directions and problems that have to be addressed are briefly discussed.read more
Citations
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Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly
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Cyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions.
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Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-scavenging tissue adhesive for highly efficient regenerative wound healing.
Haibin Wu,Fangyuan Li,Shuaifei Wang,Jingxiong Lu,Jinquan Li,Yang Du,Xiaolian Sun,Xiaoyuan Chen,Jian-Qing Gao,Daishun Ling +9 more
TL;DR: A highly versatile ROS-scavenging tissue adhesive nanocomposite synthesized by immobilizing ultrasmall ceria nanocrystals onto the surface of uniform mesoporous silica nanoparticles (MSN) not only has strong tissue adhesion strength, but also significantly restricts ROS exacerbation mediated deleterious effects, which efficiently accelerates the wound healing process.
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Nanoparticle Characterization: What to Measure?
TL;DR: The intention is to improve comparability of nanoparticle properties and performance to ensure the successful transfer of scientific knowledge to industrial real-world applications.
Journal ArticleDOI
Responsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapy of Deep Tumors.
Fangyuan Li,Yang Du,Jianan Liu,Heng Sun,Jin Wang,Ruiqing Li,Dokyoon Kim,Taeghwan Hyeon,Daishun Ling +8 more
TL;DR: The development of tumor‐pH‐sensitive photodynamic nanoagents (PPNs) comprised of self‐assembled photosensitizers grafted pH‐responsive polymeric ligands and UCNPs demonstrates the attractive properties of both UCNP‐mediated deep‐tissue penetration of light and high therapeutic selectivity in vitro and in vivo.
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