Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial.
Lior Carmi,Aron Tendler,Alexander Bystritsky,Eric Hollander,Daniel M. Blumberger,Jeff Daskalakis,Herbert E. Ward,Kyle A.B. Lapidus,Wayne K. Goodman,Leah S. Casuto,David Feifel,Noam Barnea-Ygael,Yiftach Roth,Abraham Zangen,Joseph Zohar +14 more
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TLDR
High-frequency dTMS over the medial prefrontal cortex and anterior cingulate cortex significantly improved OCD symptoms and may be considered as a potential intervention for patients who do not respond adequately to pharmacological and psychological interventions.Abstract:
Objective:Obsessive-compulsive disorder (OCD) is a chronic and disabling condition that often responds unsatisfactorily to pharmacological and psychological treatments. Converging evidence suggests...read more
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Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)
Jean Pascal Lefaucheur,André Aleman,Chris Baeken,David H. Benninger,Jerome Brunelin,Vincenzo Di Lazzaro,Saša R. Filipović,Christian Grefkes,Alkomiet Hasan,Friedhelm C. Hummel,Satu K. Jääskeläinen,Berthold Langguth,Letizia Leocani,Alain Londero,Raffaele Nardone,Jean-Paul Nguyen,Thomas Nyffeler,Albino J. Oliveira-Maia,A. Oliviero,Frank Padberg,Ulrich Palm,Walter Paulus,Emmanuel Poulet,Angelo Quartarone,Fady Rachid,Irena Rektorová,Simone Rossi,Hanna Sahlsten,Martin Schecklmann,David Szekely,Ulf Ziemann +30 more
TL;DR: These updated recommendations take into account all rTMS publications, including data prior to 2014, as well as currently reviewed literature until the end of 2018, and are based on the differences reached in therapeutic efficacy of real vs. sham rT MS protocols.
Journal ArticleDOI
Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder.
Elizabeth Shephard,Elizabeth Shephard,Emily R. Stern,Odile A. van den Heuvel,Daniel L. C. Costa,Marcelo C. Batistuzzo,Priscilla B. G. Godoy,Antonio Carlos Lopes,Andre R. Brunoni,Marcelo Q. Hoexter,Roseli G. Shavitt,Y.C. Janardhan Reddy,Christine Lochner,Dan J. Stein,H. Blair Simpson,Euripedes Constantino Miguel +15 more
TL;DR: In this paper, a heuristic neurocircuit-based taxonomy is proposed to guide the treatment of OCD by integrating information from cognitive neuroscience and neuroimaging research, including case vignettes in which patients with OCD describe their symptoms and discuss different clinical profiles in the phenotypic expression of the condition.
Journal ArticleDOI
Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders
Naomi A. Fineberg,Naomi A. Fineberg,Naomi A. Fineberg,Eric Hollander,Stefano Pallanti,Stefano Pallanti,Susanne Walitza,Edna Grünblatt,Bernardo Dell'Osso,Umberto Albert,Daniel A. Geller,Vlasios Brakoulias,Y.C. Janardhan Reddy,Shyam Sundar Arumugham,Roseli G. Shavitt,Lynne M. Drummond,Benedetta Grancini,Benedetta Grancini,Vera De Carlo,Vera De Carlo,Eduardo Cinosi,Eduardo Cinosi,Samuel R. Chamberlain,Samuel R. Chamberlain,Konstantinos Ioannidis,Konstantinos Ioannidis,Carolyn I. Rodriguez,Carolyn I. Rodriguez,Kabir Garg,David J. Castle,Michael Van Ameringen,Michael Van Ameringen,Dan J. Stein,Lior Carmi,Lior Carmi,Joseph Zohar,Joseph Zohar,José M. Menchón +37 more
TL;DR: The article presents those selected therapeutic advances judged to be of utmost relevance to the treatment of OCD, based on new and emerging evidence from clinical and translational science.
Journal ArticleDOI
Repetitive transcranial magnetic stimulation for smoking cessation: a pivotal multicenter double-blind randomized controlled trial
Abraham Zangen,Hagar Moshe,Diana Martinez,Noam Barnea-Ygael,Tanya Vapnik,Alexander Bystritsky,Walter Duffy,Doron Toder,Doron Toder,Leah S. Casuto,Moran Lipkinsky Grosz,Edward V. Nunes,Herbert E. Ward,Aron Tendler,David Feifel,Oscar G. Morales,Yiftach Roth,Dan V. Iosifescu,Jaron Winston,Theodore Wirecki,Ahava Stein,Frederic Deutsch,Xingbao Li,Mark S. George,Mark S. George +24 more
TL;DR: In this article, the authors conducted a multicenter double-blind RCT in 262 chronic smokers meeting DSM-5 criteria for tobacco use disorder, who had made at least one prior failed attempt to quit.
Journal ArticleDOI
Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder
TL;DR: In this article, a review focuses on several promising areas of research that may help elucidate the pathophysiology of OCD and advance treatment and provides evidence for increased activity in brain regions that form a cortico-striato-thalamo-cortical (CSTC) loop, which is a common substrate for various interventions (whether drug, behavioral, or device) may be modulation (at different nodes or connections) of the CSTC circuit that mediates the symptoms of OCD.
References
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