Journal ArticleDOI
Elevated serum mitochondrial DNA in females and lack of altered platelet mitochondrial methylation in patients with Parkinson´s disease.
Amit Sharma,Simon T. Schaefer,Chanachai Sae-Lee,Chanachai Sae-Lee,Hyang-Min Byun,Ullrich Wüllner +5 more
TLDR
It is shown that the mitochondrial epigenome does harbor detectable CpG methylation sites in platelets-derived DNA, in context to the ongoing debate about mtDNA methylation.Abstract:
Purpose: Mitochondrial dysfunction has long been considered in the pathogenesis of Parkinson's disease (PD). This is evident from the presence of mitochondrial DNA deletions in substantia nigra neu...read more
Citations
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Mitochondrial DNA Methylation and Human Diseases
Andrea Stoccoro,Fabio Coppedè +1 more
TL;DR: In this article, the mtDNA methylation and hydroxymethylation levels of mtDNA have been found in animal models and in human tissues from patients affected by cancer, obesity, diabetes and cardiovascular and neurodegenerative diseases.
Journal ArticleDOI
Mitochondrial Dysfunction in Parkinson’s Disease: From Mechanistic Insights to Therapy
TL;DR: This review aims to describe mitochondrial dysfunction in the pathology of PD, outline the genes associated with familial PD and the factors related to sporadic PD, summarize current knowledge on mitochondrial quality control in PD, and give an overview of therapeutic strategies for targeting mitochondria in neuroprotective interventions in PD.
Journal ArticleDOI
Mitochondria and Mitochondrial DNA: Key Elements in the Pathogenesis and Exacerbation of the Inflammatory State Caused by COVID-19.
José J. Valdés-Aguayo,Idalia Garza-Veloz,Jose I. Badillo-Almaraz,Sofía Bernal-Silva,Maria C. Martínez-Vázquez,Vladimir Juárez-Alcalá,José R. Vargas-Rodríguez,María L. Gaeta-Velasco,Carolina González-Fuentes,Lorena Avila-Carrasco,Margarita L Martinez-Fierro +10 more
TL;DR: In this article, the importance of mitochondria in inflammatory pathologies, besides providing energy, is associated with the release of mitochondrial damage products such as mt-DNA, which may perpetuate inflammation.
Journal ArticleDOI
Mitochondrial d-loop region methylation and copy number in peripheral blood dna of parkinson’s disease patients
Andrea Stoccoro,Adam Smith,Filippo Baldacci,Claudia Del Gamba,Annalisa Lo Gerfo,Roberto Ceravolo,Katie Lunnon,Lucia Migliore,Fabio Coppedè +8 more
TL;DR: In this paper, the mtDNA copy number and D-loop methylation levels of 30 Parkinson's disease patients and 30 age-and sex-matched control subjects were analyzed by quantitative PCR.
Journal ArticleDOI
Increase in Mitochondrial D-Loop Region Methylation Levels in Mild Cognitive Impairment Individuals
Andrea Stoccoro,Filippo Baldacci,Roberto Ceravolo,Linda Giampietri,Gloria Tognoni,Gabriele Siciliano,Lucia Migliore,Fabio Coppedè +7 more
TL;DR: The present pilot study shows that peripheral D-loop methylation levels differ in patients at different stages of AD pathology, suggesting that further studies deserve to be performed in order to validate the usefulness of D- loop methylation analysis as a peripheral biomarker for the early detection of AD.
References
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Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
TL;DR: It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.
Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
Journal ArticleDOI
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.
Andreas Bender,Kim J. Krishnan,Christopher Morris,Geoffrey A. Taylor,Amy K. Reeve,Robert H. Perry,Evelyn Jaros,Joshua S Hersheson,Joanne Betts,Thomas Klopstock,Robert W. Taylor,Douglass M. Turnbull +11 more
TL;DR: It is shown that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA, suggesting that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease.
Journal ArticleDOI
Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
Latha Devi,Vijayendran Raghavendran,Badanavalu M. Prabhu,Narayan G. Avadhani,Hindupur K. Anandatheerthavarada +4 more
TL;DR: Evidence is provided that mitochondria of PD-vulnerable substantia nigra and striatum but not cerebellum from PD subjects showed significant accumulation of α-synuclein and decreased complex I activity, which provides evidence that mitochondrial accumulated α- synuclein may interact with complex I and interfere with its functions.
Journal ArticleDOI
Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives.
TL;DR: Increasing evidence supports the critical role for mitochondrial dysfunction in the development of sporadic PD, while the involvement of familial PD-related genes in the regulation of mitochondrial biology has been expanded by the discovery of new mitochondria-associated disease loci and the identification of their novel functions.