Epithelial m cells : gateways for mucosal infection and immunization
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TLDR
Future studies on the interactions of micoorganisms with this highly specialized epithelial cell will enhance the understanding of microbial pathogenesis and will lead to more effective strategies for targeting of vaccines and live microbial vaccine vectors to the mucosal immune system.About:
This article is published in Cell.The article was published on 1996-08-09 and is currently open access. It has received 553 citations till now. The article focuses on the topics: Mucosal Infection & Intestinal mucosa.read more
Citations
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Journal ArticleDOI
CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Jan Hendrik Niess,Stephan Brand,Xiubin Gu,Limor Landsman,Steffen Jung,Beth A. McCormick,Jatin M. Vyas,Marianne Boes,Hidde L. Ploegh,James G. Fox,Dan R. Littman,Hans Christian Reinecker +11 more
TL;DR: A myeloid-derived mucosal DC in mice is identified, which populates the entire lamina propria of the small intestine, and CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
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Origin, maturation and antigen presenting function of dendritic cells
TL;DR: Dendritic cells represent the natural adjuvants for T cell responses and their therapeutic exploitation in the near future is foreseen.
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The role of chemokine receptors in primary, effector, and memory immune responses.
TL;DR: The immune system is composed of single cells, and its function is entirely dependent on the capacity of these cells to traffic, localize within tissues, and interact with each other in a precisely coordinated fashion.
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Vaccine adjuvants: current state and future trends.
TL;DR: The state of the art in the adjuvant field is reviewed, future directions of adjUvant development are explored, some of the impediments and barriers to development and registration of new human adjuvants are examined and some of those barriers are examined are examined.
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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
Thaher Pelaseyed,Joakim H. Bergström,Jenny K. Gustafsson,Anna Ermund,George M. H. Birchenough,André Schütte,Sjoerd van der Post,Frida Svensson,Ana M. Rodríguez-Piñeiro,Elisabeth E. L. Nyström,Catharina Wising,Malin E. V. Johansson,Gunnar C. Hansson +12 more
TL;DR: The mucus and epithelial cells of the gastrointestinal tract are the primary gate keepers and controllers of bacterial interactions with the host immune system, but the understanding of this relationship is still in its infancy.
References
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The mucosal immune system : from fundamental concepts to vaccine development
Jerry R. McGhee,Jiri Mestecky,Mark T. Dertzbaugh,John H. Eldridge,Masatomo Hirasawa,Hiroshi Kiyono +5 more
TL;DR: Practical approaches for vaccine construction and delivery into mucosal inductive sites in an effort to elicit host protection at mucosal surfaces where the infection actually occurs are proposed.
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Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.
TL;DR: Invasion of M cells was associated with the ability of the bacteria to invade tissue culture cells, and replicating Salmonella began to enter both the apical and basolateral surfaces of enterocytes adjacent to infected M cells.
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Antigen sampling across epithelial barriers and induction of mucosal immune responses
TL;DR: The features of M cells that determine antigen and pathogen adherence and transport into mucosal lymphoid tissues are reviewed.
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Biodegradable microspheres as a vaccine delivery system
John H. Eldridge,Jay K. Staas,J A Meulbroek,Jerry R. McGhee,Thomas R. Tice,Richard M. Gilley +5 more
TL;DR: Results indicate that biodegradable and biocompatible microspheres represent an adjuvant system with potentially widespread application in the induction of both circulating and mucosal immunity.
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Koji Hase,Kazuya Kawano,Tomonori Nochi,Gemilson Soares Pontes,Shinji Fukuda,Masashi Ebisawa,Kazunori Kadokura,Toru Tobe,Yumiko Fujimura,Sayaka Kawano,Atsuko Yabashi,Satoshi Waguri,Gaku Nakato,Shunsuke Kimura,Takaya Murakami,Mitsutoshi Iimura,Kimiyo Hamura,Shin Ichi Fukuoka,Anson W. Lowe,Kikuji Itoh,Hiroshi Kiyono,Hiroshi Ohno +21 more