Journal ArticleDOI
Estrogenic endocrine disruptors: Molecular mechanisms of action.
Ryoiti Kiyama,Yuko Wada-Kiyama +1 more
TLDR
A comprehensive summary of more than 450 estrogenic chemicals including estrogenic endocrine disruptors is provided here to understand the complex and profound impact of estrogen action.About:
This article is published in Environment International.The article was published on 2015-10-01. It has received 193 citations till now.read more
Citations
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Journal ArticleDOI
Oyster reproduction is affected by exposure to polystyrene microplastics
Rossana Sussarellu,Marc Suquet,Yoann Thomas,Christophe Lambert,Caroline Fabioux,Marie Eve Julie Pernet,Nelly Le Goïc,Virgile Quillien,Christian Mingant,Yanouk Epelboin,Charlotte Corporeau,J. Guyomarch,Johan Robbens,Ika Paul-Pont,Philippe Soudant,Arnaud Huvet +15 more
TL;DR: Evidence is provided that micro-PS cause feeding modifications and reproductive disruption in oysters, with significant impacts on offspring, providing ground-breaking data on microplastic impacts in an invertebrate model, helping to predict ecological impact in marine ecosystems.
Journal ArticleDOI
Pharmaceuticals and personal care products in waters: occurrence, toxicity, and risk.
TL;DR: The combination of increasing global population size and potential droughts may result in reduced water availability, increased need for water reuse, and increasing concentrations of PPCP in wastewaters, which leads to concerns about the sustainability of global water supplies.
Journal ArticleDOI
Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors
TL;DR: The findings of the bioassays have demonstrated that ePAHs have the ability to affect the endocrine systems of humans and animals, and standardized assay protocols for pathway-based assessments are considered to be important to overcome these issues.
Journal ArticleDOI
Prevalence and hazardous impact of pharmaceutical and personal care products and antibiotics in environment: A review on emerging contaminants
Preeti Chaturvedi,Preeti Chaturvedi,Parul Shukla,Balendu Shekher Giri,Pankaj Chowdhary,Ram Chandra,Pratima Gupta,Ashok Pandey +7 more
TL;DR: In this article, the major sources responsible for emergence of antibiotic resistance are elucidated and a variety of introductory sources and fate of PPCPs in aquatic environment including human and veterinary wastes, aquaculture and agriculture related wastes, and other anthropogenic activities have been discussed.
Journal ArticleDOI
Constraints and Priorities for Conducting Experimental Exposures of Marine Organisms to Microplastics
Ika Paul-Pont,Kevin Tallec,Carmen González-Fernández,Christophe Lambert,Dorothée Vincent,David Mazurais,José-Luis Zambonino-Infante,Guillaume Brotons,Fabienne Lagarde,Caroline Fabioux,Philippe Soudant,Arnaud Huvet +11 more
TL;DR: In this article, the authors review constraints and priorities for conducting experimental exposures of marine wildlife to microplastics based on the literature, feedback from peer reviewers and knowledge gained from their experience.
References
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Journal ArticleDOI
TGF-beta signal transduction.
TL;DR: The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms and mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
Journal ArticleDOI
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.
George G. J. M. Kuiper,J.G. Lemmen,Bo Carlsson,J. Christopher Corton,Stephen Safe,Paul T. van der Saag,Bart van der Burg,Jan-Åke Gustafsson +7 more
TL;DR: The estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ERα or ERβ protein, and in a transient gene expression assay using cells in which an acute estrogenic response is created by cotransfecting cultures with recombinant human ERβ complementary DNA (cDNA) in the presence of an estrogen-dependent reporter plasmid are investigated.
Journal ArticleDOI
The NCI60 human tumour cell line anticancer drug screen
TL;DR: The development, use and productivity of the NCI60 screen are reviewed, highlighting several outcomes that have contributed to advances in cancer chemotherapy.
Journal ArticleDOI
Mechanisms of Estrogen Action
Stefan Nilsson,Sari Mäkelä,Eckardt Treuter,Michel Tujague,Jane S. Thomsen,Göran Andersson,Eva Enmark,Katarina Pettersson,Margaret Warner,Jan-Åke Gustafsson +9 more
TL;DR: The role of estrogen receptors in physiology and pathology has been investigated in the past decade and it was found that there was not one but two distinct and functional estrogen receptors, now called ERα and ERβ.
Journal ArticleDOI
The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.
Ana M. Soto,Carlos Sonnenschein,Kerrie L. Chung,Mariana F. Fernández,Nicolás Olea,Fátima Olea Serrano +5 more
TL;DR: The aims of the work summarized in this paper were to validate the E-SCREEN assay, to screen a variety of chemicals present in the environment to identify those that may be causing reproductive effects in wildlife and humans, and to assess whether environmental estrogens may act cumulatively.