Evolutionary descent of a human chromosome 6 neocentromere: a jump back to 17 million years ago.
Oronzo Capozzi,Stefania Purgato,Pietro D'Addabbo,Nicoletta Archidiacono,Paola Battaglia,Anna Baroncini,Antonella Capucci,Roscoe Stanyon,Giuliano Della Valle,Mariano Rocchi +9 more
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TLDR
The evolutionary history of chromosome 6 in primates was investigated in detail and it was found that the primate ancestor had a homologous chromosome with the same marker order, but with the centromere located at 6p22.1.Abstract:
Molecular cytogenetics provides a visual, pictorial record of the tree of life, and in this respect the fusion origin of human chromosome 2 is a well-known paradigmatic example. Here we report on a variant chromosome 6 in which the centromere jumped to 6p22.1. ChIP-chip experiments with antibodies against the centromeric proteins CENP-A and CENPC exactly defined the neocentromere as lying at chr6:26,407–26,491 kb. We investigated in detail the evolutionary history of chromosome 6 in primates and found that the primate ancestor had a homologous chromosome with the same marker order, but with the centromere located at 6p22.1. Sometime between 17 and 23 million years ago (Mya), in the common ancestor of humans and apes, the centromere of chromosome 6 moved from 6p22.1 to its current location. The neocentromere we discovered, consequently, has jumped back to the ancestral position, where a latent centromereforming potentiality persisted for at least 17 Myr. Because all living organisms form a tree of life, as first conceived by Darwin, evolutionary perspectives can provide compelling underlying explicative grounds for contemporary genomic phenomena.read more
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The common marmoset genome provides insight into primate biology and evolution
Kim C. Worley,Wesley C. Warren,Jeffrey Rogers,Devin P. Locke,Donna M. Muzny,Elaine R. Mardis,George M. Weinstock,Suzette D. Tardif,Kjersti Aagaard,Nicoletta Archidiacono,Nirmala Arul Rayan,Mark A. Batzer,Kathryn Beal,Brona Brejova,Oronzo Capozzi,Saverio B. Capuano,Claudio Casola,Claudio Casola,Mimi M. Chandrabose,Andrew Cree,Marvin Diep Dao,Pieter J. De Jong,Pieter J. De Jong,Ricardo C.H. del Rosario,Kim D. Delehaunty,Huyen Dinh,Evan E. Eichler,Stephen Fitzgerald,Paul Flicek,Catherine C. Fontenot,R. Gerald Fowler,Catrina Fronick,Lucinda Fulton,Robert S. Fulton,Ramatu Ayiesha Gabisi,Daniel Gerlach,Daniel Gerlach,Tina Graves,Preethi H. Gunaratne,Preethi H. Gunaratne,Matthew W. Hahn,David Haig,Yi Han,R. Alan Harris,Javier Herrero,LaDeana W. Hillier,Robert Hubley,Jennifer F. Hughes,Jennifer Hume,Shalini N. Jhangiani,Lynn B. Jorde,Vandita Joshi,Emre Karakor,Miriam K. Konkel,Carolin Kosiol,Christie LKovar,Evgenia V. Kriventseva,Sandra L. Lee,Lora Lewis,Yih Shin Liu,John Lopez,Carlos López-Otín,Belen Lorente-Galdos,Keith G. Mansfield,Keith G. Mansfield,Tomas Marques-Bonet,Patrick Minx,Doriana Misceo,Doriana Misceo,J. Scott Moncrieff,Margaret Morgan,Lynne V. Nazareth,Irene Newsham,Ngoc Nguyen,Geoffrey Okwuonu,Shyam Prabhakar,Lora Perales,Ling Ling Pu,Xose S. Puente,Víctor Quesada,Megan C. Ranck,Brian J. Raney,Muthuswamy Raveendran,David Rio Deiros,Mariano Rocchi,David Rodríguez,Corinna N. Ross,Magali Ruffier,San Juana Ruiz,Saba Sajjadian,Jireh Santibanez,Daniel R. Schrider,Steve Searle,Helen Skaletsky,Helen Skaletsky,Benjamin Soibam,Arian F.A. Smit,Jayantha B. Tennakoon,Lubomir Tomaska,Brygg Ullmer,Charles E. Vejnar,Mario Ventura,Albert J. Vilella,Tomas Vinar,Jan Hinnerk Vogel,Jerilyn A. Walker,Qing Wang,Crystal M. Warner,Derek E. Wildman,David J. Witherspoon,Rita A. Wright,Yuanqing Wu,Weimin Xiao,Jinchuan Xing,Jinchuan Xing,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Baoli Zhu,Richard A. Gibbs,Rick K. Wilson +120 more
TL;DR: The whole-genome sequence of the common marmoset enables increased power for comparative analyses among available primate genomes and facilitates biomedical research application.
Journal ArticleDOI
Centromere repositioning in mammals
TL;DR: A review of the centromere repositioning is provided, new data on the population genetics of the ENC of the orangutan is added, and for the first time an ENC is described on the X chromosome of squirrel monkeys.
Journal ArticleDOI
Complete genomic and epigenetic maps of human centromeres
TL;DR: In this paper , a complete, telomere-to-telomere human genome assembly (T2T-CHM13) has enabled the comprehensively characterize pericentromeric and centromeric repeats, which constitute 6.2% of the genome.
Journal ArticleDOI
Neocentromeres and epigenetically inherited features of centromeres.
Laura S. Burrack,Judith Berman +1 more
TL;DR: Analysis of neocentromeres found in human clinical samples and induced in model organisms distinguishes features of centromeres that are dependent on centromere DNA from features that are epigenetically inherited together with the formation of a functional kinetochore.
Journal ArticleDOI
Centromere inactivation and epigenetic modifications of a plant chromosome with three functional centromeres
TL;DR: A transmissible chromosome with multiple centromeres in wheat that encompassed one large and two small domains containing the centromeric histone CENH3 showed characteristics typical to dicentric chromosomes, including chromosome breaks and centromere inactivation.
References
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Journal ArticleDOI
The origin of man: a chromosomal pictorial legacy
Jorge J. Yunis,Om Prakash +1 more
TL;DR: A comparative analysis of high-resolution chromosomes from orangutan, gorilla, chimpanzee, and man suggests that 18 or 23 pairs of chromosomes of modern man are virtually identical to those of the authors' "common hominoid ancestor", with the remaining pairs slightly different.
Journal ArticleDOI
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TL;DR: The entire mitochondrial DNA genomes from a representative of three cercopithecoid tribes are sequenced, and divergence dates using a penalized likelihood and a Bayesian method are estimated, both of which take into account the effects of rate differences on lineages, phylogenetic tree structure, and multiple calibration points.
Journal ArticleDOI
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Pavel A. Pevzner,Glenn Tesler +1 more
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