Journal ArticleDOI
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
TLDR
Animal and human studies indicate that exercise provides a powerful stimulus that can countervail the molecular changes that underlie the progressive loss of hippocampal function in advanced age and AD.About:
This article is published in Neurobiology of Disease.The article was published on 2013-09-01. It has received 255 citations till now. The article focuses on the topics: Dementia.read more
Citations
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Amyloid beta: structure, biology and structure-based therapeutic development
Guo Fang Chen,Ting-Hai Xu,Yan Yan,Yu Ren Zhou,Yi Jiang,Karsten Melcher,H. Eric Xu,H. Eric Xu +7 more
TL;DR: The structures, biological functions, and neurotoxicity role of Aβ are reviewed, the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and metabolism are discussed, and the therapeutic developments and recent advances of different strategies for treating Alzheimer's disease are summarized.
Journal ArticleDOI
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
TL;DR: Current research on the interplay and sequence of oxidative damage related to impaired brain glucose metabolism and proteostasis defects are summarized and potential pharmacological interventions to retard AD progression are suggested.
Journal ArticleDOI
Bridging animal and human models of exercise-induced brain plasticity.
TL;DR: In this paper, the influence of exercise on hippocampal structure and function, addressing common themes such as spatial memory and pattern separation, brain structure and plasticity, neurotrophic factors, and vasculature.
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's diseases
TL;DR: In this article, the authors used TgCRND8 mice to examine directly the interaction between exercise and the AD cascade, and found that five months of voluntary exercise resulted in a decrease in extracellular amyloid-β (Aβ) plaques in the frontal cortex.
Journal ArticleDOI
Beneficial effects of physical exercise on neuroplasticity and cognition.
Kirsten Hötting,Brigitte Röder +1 more
TL;DR: The results suggest that physical exercise may trigger processes facilitating neuroplasticity and, thereby, enhances an individual's capacity to respond to new demands with behavioral adaptations.
References
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Journal ArticleDOI
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
Christian Haass,Dennis J. Selkoe +1 more
TL;DR: Findings in other neurodegenerative diseases indicate that a broadly similar process of neuronal dysfunction is induced by diffusible oligomers of misfolded proteins.
Journal ArticleDOI
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Karen Hsiao,Paul F. Chapman,Steven P. Nilsen,Chris Eckman,Yasuo Harigaya,Steven G. Younkin,Fusheng Yang,Greg M. Cole +7 more
TL;DR: Transgenic mice overexpressing the 695-amino acid isoform of human Alzheimer β-amyloid (Aβ) precursor protein containing a Lys670 → Asn, Met671 → Leu mutation had normal learning and memory but showed impairment by 9 to 10 months of age.
Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
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