Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis
Pengfei Liu,Pengfei Liu,Yetong Feng,Hanwei Li,Hanwei Li,Xin Chen,Guangsuo Wang,Shiyuan Xu,Yalan Li,Lei Zhao,Lei Zhao +10 more
TLDR
It is indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroPTosis may become a novel target in the treatment of ALI patients.Abstract:
Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4, while the levels of MDA, 4-HNE and total iron were increased by LPS treatment in a dose-dependent manner, which could be rescued by Fer-1. The results of the in vivo experiment also indicated that Fer-1 exerted therapeutic action against LPS-induced ALI, and down-regulated the ferroptosis level in lung tissues. Our study indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroptosis may become a novel target in the treatment of ALI patients.read more
Citations
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The mechanism of monobutyl phthalate -induced ferroptosis via TNF/IL6/STAT3 signal pathway in TM-3 cells.
TL;DR: In this article , the authors evaluated the mechanism of MBP-induced ferroptosis in reproductive damage, bioinformation analysis and experimental validation were used to evaluate the mechanism and the specific mechanism of reproductive injury caused by MBP.
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Ferrostatin-1 alleviates the damage of C2C12 myoblast and mouse pelvic floor muscle induced by mechanical trauma
TL;DR: In this article , the role of ferroptosis-associated oxidative mechanisms in mechanical stretching-induced pelvic floor muscle injury was explored, and whether obesity predisposed the muscle to FerroPTosis from mechanical injury.
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Ferrostatin-1 ameliorates Bupivacaine-Induced spinal neurotoxicity in rats by inhibiting ferroptosis
Yang Zhao,Yunpeng Luo,Yuanyuan Chen,Liling Wei,Xiaodan Luo,Gang Zhou,Jian Lai,Jiemei Ji,Yunan Lin,Jing-Chen Liu +9 more
TL;DR: In this paper , the authors investigated the impact of ferroptosis on BUP-induced neurotoxicity in the spinal cord and found that Ferrostatin-1 (Fer-1) can provide protection against BUPinduced spinal neurotoxicity.
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Moxibustion ameliorates cerebral ischemia-reperfusion injury by regulating ferroptosis in rats.
TL;DR: In this paper , the authors investigated the effect of moxibustion on cerebral ischemia-reperfusion injury (CIRI) in rats and found that it could reduce nerve function damage and neuronal death.
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Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential
TL;DR: In this article , the authors highlight the mechanisms underlying mitochondrial dysfunctions and how this key event contributes to inflammatory response as well as cell death modes during cerebral ischemia/reperfusion injury.
References
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
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Journal ArticleDOI
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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