Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis
Pengfei Liu,Pengfei Liu,Yetong Feng,Hanwei Li,Hanwei Li,Xin Chen,Guangsuo Wang,Shiyuan Xu,Yalan Li,Lei Zhao,Lei Zhao +10 more
TLDR
It is indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroPTosis may become a novel target in the treatment of ALI patients.Abstract:
Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position of ferroptosis in lipopolysaccharide (LPS)-induced acute lung injury (ALI) has not been explored intensively so far. In this study, we mainly analyzed the relationship between ferroptosis and LPS-induced ALI. In this study, a human bronchial epithelial cell line, BEAS-2B, was treated with LPS and ferrostatin-1 (Fer-1, ferroptosis inhibitor). The cell viability was measured using CCK-8. Additionally, the levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and iron, as well as the protein level of SLC7A11 and GPX4, were measured in different groups. To further confirm the in vitro results, an ALI model was induced by LPS in mice, and the therapeutic action of Fer-1 and ferroptosis level in lung tissues were evaluated. The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4, while the levels of MDA, 4-HNE and total iron were increased by LPS treatment in a dose-dependent manner, which could be rescued by Fer-1. The results of the in vivo experiment also indicated that Fer-1 exerted therapeutic action against LPS-induced ALI, and down-regulated the ferroptosis level in lung tissues. Our study indicated that ferroptosis has an important role in the progression of LPS-induced ALI, and ferroptosis may become a novel target in the treatment of ALI patients.read more
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Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice.
Xiaohong Zhang,Mengxin Tian,Xin Li,Chunyan Zheng,Ai-lian Wang,Jundong Feng,Xiaodan Hu,Shuquan Chang,Haiqian Zhang,Haiqian Zhang,Haiqian Zhang +10 more
TL;DR: Baicalein (an anti-ferroptosis drug) was recently reported to synergistically improve the survival rate of mice following a high dose of total body irradiation with anti-apoptosis and anti-necropto...
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Extracellular Matrix and Oxidative Stress Following Traumatic Spinal Cord Injury: Physiological and Pathophysiological Roles and Opportunities for Therapeutic Intervention.
B. Surya Rajan,Jonathon Chon Teng Chio,Nayaab Punjani,Nader Hejrati,Mohammad-Masoud Zavvarian,James Hong,Michael G. Fehlings +6 more
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Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway.
Wenyu Qiu,Xinting Zhang,Xiaoyue Pang,Jianjiang Huang,Shuilian Zhou,Rongmei Wang,Zhaoxin Tang,Rongsheng Su +7 more
TL;DR: In this paper , the effect of AA on LPS-induced acute kidney injury (AKI) in broilers was explored, and the mRNA and protein expressions related to oxidative stress and ferroptosis were tested by qPCR and western blotting respectively.
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Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats.
Danyun Jia,Jinyu Zheng,Yiyang Zhou,Jinqiu Jia,Xiaoxiao Ye,Bingbing Zhou,Xingxing Chen,Yunchang Mo,Junlu Wang +8 more
TL;DR: In this paper, the authors evaluated whether ferroptosis is involved in hyperoxic acute lung injury (HALI) and its mechanisms through the HALI model, and showed pathological changes with larger and fewer alveoli and thicker alveolar septa after HE staining.
Journal ArticleDOI
Molecular mechanisms of ferroptosis and relevance to inflammation
TL;DR: In this paper , the authors summarize the regulatory mechanisms associated with ferroptosis, discuss the interaction between ferroPTosis and inflammation, the role of mitochondria in inflammatory ferrosinosis, and the role the targeting of targeting ferrotransosis in inflammatory diseases.
References
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
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