Journal ArticleDOI
From research to phase III: Preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine
TLDR
The different steps and challenges of developing CYD TDV are discussed, from research to industrialization, and some of the challenges to the successful introduction of a dengue vaccine into immunization programs are summarized.About:
This article is published in Vaccine.The article was published on 2011-09-23. It has received 302 citations till now. The article focuses on the topics: Dengue vaccine & Yellow fever vaccine.read more
Citations
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Journal ArticleDOI
Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial
Maria Rosario Capeding,Ngoc Huu Tran,Sri Rezeki Hadinegoro,Hussain Imam Muhammad Ismail,Tawee Chotpitayasunondh,Mary Noreen Chua,Chan Quang Luong,Kusnandi Rusmil,Dewa Nyoman Wirawan,Revathy Nallusamy,Punnee Pitisuttithum,Usa Thisyakorn,In-Kyu Yoon,Diane van der Vliet,Edith Langevin,Thelma Laot,Yanee Hutagalung,Carina Frago,Mark Boaz,T. Anh Wartel,Nadia Tornieporth,Melanie Saville,Alain Bouckenooghe +22 more
TL;DR: The findings show that dengue vaccine is efficacious when given as three injections at months 0, 6, and 12 to children aged 2-14 years in endemic areas in Asia, and has a good safety profile.
Journal ArticleDOI
Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America
Luis Angel Villar,Gustavo H. Dayan,José Luis Arredondo-García,Doris Maribel Rivera,Rivaldo Venâncio da Cunha,Carmen Deseda,Humberto Reynales,Maria Selma N. Costa,Javier O Morales-Ramirez,Gabriel Carrasquilla,Luis Carlos Rey,Reynaldo Dietze,Kleber Giovanni Luz,Enrique Rivas,Maria Consuelo Miranda Montoya,Margarita Cortés Supelano,Betzana Zambrano,Edith Langevin,Mark Boaz,Nadia Tornieporth,Melanie Saville,Fernando Noriega +21 more
TL;DR: The CYD-TDV dengue vaccine was efficacious against V CD and severe VCD and led to fewer hospitalizations for VCD in five Latin American countries where d Dengue is endemic.
Journal ArticleDOI
Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial
Arunee Sabchareon,Derek Wallace,Chukiat Sirivichayakul,Kriengsak Limkittikul,Pornthep Chanthavanich,Saravudh Suvannadabba,Vithaya Jiwariyavej,Wut Dulyachai,Krisana Pengsaa,T. Anh Wartel,Annick Moureau,Melanie Saville,Alain Bouckenooghe,Simonetta Viviani,Nadia Tornieporth,Jean Lang +15 more
TL;DR: These data show for the first time that a safe vaccine against dengue is possible, and Dengue vaccine was well tolerated, with no safety signals after 2 years of follow-up after the first dose.
Journal ArticleDOI
Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells
Daniela Weiskopf,Michael A. Angelo,Elzinandes Leal de Azeredo,John Sidney,Jason A. Greenbaum,Anira N. Fernando,Anne Broadwater,Ravi Kolla,Aruna D. De Silva,Aruna D. De Silva,Aravinda M. de Silva,Kimberly-Anne Mattia,Benjamin J. Doranz,Howard M. Grey,Sujan Shresta,Bjoern Peters,Alessandro Sette +16 more
TL;DR: Higher magnitude and more polyfunctional responses for HLA alleles associated with decreased susceptibility to severe disease are demonstrated, suggesting that a vigorous response by multifunctional CD8+ T cells is associated with protection from dengue virus disease.
Journal Article
Dengue in India
TL;DR: The extent of work done by various groups of scientists in India on various problems of dengue disease is reviewed, finding a lot remain to be achieved for creating an impact.
References
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Journal ArticleDOI
Dengue: a continuing global threat
María G. Guzmán,Scott B. Halstead,Harvey Artsob,Philippe Buchy,Jeremy Farrar,Duane J. Gubler,Elizabeth Hunsperger,Axel Kroeger,Harold S. Margolis,Eric Martinez,Michael B. Nathan,José L. Pelegrino,Cameron P. Simmons,Sutee Yoksan,Rosanna W. Peeling,Rosanna W. Peeling +15 more
TL;DR: A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated.
Journal ArticleDOI
Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.
Journal ArticleDOI
Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
Juthathip Mongkolsapaya,Wanwisa Dejnirattisai,Xiao-Ning Xu,Sirijitt Vasanawathana,Nattaya Tangthawornchaikul,Aroonrung Chairunsri,Siraporn Sawasdivorn,Thaneeya Duangchinda,Tao Dong,Sarah Rowland-Jones,Pa-thai Yenchitsomanus,Andrew J. McMichael,Prida Malasit,Prida Malasit,Gavin R. Screaton +14 more
TL;DR: Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T- cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
Journal ArticleDOI
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
Stephane Daffis,Kristy J. Szretter,Jill Schriewer,Jianqing Li,Soonjeon Youn,John S. Errett,Tsai-Yu Lin,Stewart W. Schneller,Roland Züst,Hongping Dong,Volker Thiel,Volker Thiel,Ganes C. Sen,Volker Fensterl,William B. Klimstra,Theodore C. Pierson,R. Mark L. Buller,Michael Gale,Pei Yong Shi,Michael S. Diamond +19 more
TL;DR: It is demonstrated that a West Nile virus mutant that lacks 2′-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling, and suggested an evolutionary explanation for 2-O methylation of cellular mRNA: to distinguish self from non-self RNA.
Journal ArticleDOI
Human skin Langerhans cells are targets of dengue virus infection.
Shuenn-Jue L. Wu,Geraldine Grouard-Vogel,Wellington Sun,John R. Mascola,Elena F. Brachtel,Elena F. Brachtel,Ravithat Putvatana,Mark K. Louder,Luis Filgueira,Mary A. Marovich,Henry K. Wong,Andrew Blauvelt,Gerald S. Murphy,Gerald S. Murphy,Merlin L. Robb,Bruce L. Innes,Deborah L. Birx,Curtis G. Hayes,Sarah Schlesinger Frankel,Sarah Schlesinger Frankel +19 more
TL;DR: Data demonstrate that human skin dendritic cells are permissive for DV infection, and provide a potential mechanism for the transmission of DV into human skin.
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