Heterogeneity in breast cancer
TLDR
The articles in this Review series discuss recent advances in the understanding of breast tumor heterogeneity, therapies tailored based on this knowledge, and future ways of assessing and treating heterogeneous tumors.Abstract:
Breast cancer is a heterogeneous disease. There is a high degree of diversity between and within tumors as well as among cancer-bearing individuals, and all of these factors together determine the risk of disease progression and therapeutic resistance. Advances in technologies such as whole-genome sequencing and functional viability screens now allow us to analyze tumors at unprecedented depths. However, translating this increasing knowledge into clinical practice remains a challenge in part due to tumor evolution driven by the diversity of cancer cell populations and their microenvironment. The articles in this Review series discuss recent advances in our understanding of breast tumor heterogeneity, therapies tailored based on this knowledge, and future ways of assessing and treating heterogeneous tumors.read more
Citations
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SF-010-4 Distant metastasis occurs late during the genetic evolution of pancreatic cancer
TL;DR: A quantitative analysis of the timing of the genetic evolution of pancreatic cancer was performed, indicating at least a decade between the occurrence of the initiating mutation and the birth of the parental, non-metastatic founder cell.
Journal ArticleDOI
Proteogenomics connects somatic mutations to signalling in breast cancer
Philipp Mertins,D. R. Mani,Kelly V. Ruggles,Michael A. Gillette,Michael A. Gillette,Karl R. Clauser,Pei Wang,Xianlong Wang,Jana W. Qiao,Song Cao,Francesca Petralia,Emily Kawaler,Filip Mundt,Filip Mundt,Karsten Krug,Zhidong Tu,Jonathan T. Lei,Michael L. Gatza,Matthew D. Wilkerson,Charles M. Perou,Venkata Yellapantula,Kuan-lin Huang,Chenwei Lin,Michael D. McLellan,Ping Yan,Sherri R. Davies,R. Reid Townsend,Steven J. Skates,Jing Wang,Bing Zhang,Christopher R. Kinsinger,Mehdi Mesri,Henry Rodriguez,Li Ding,Amanda G. Paulovich,David Fenyö,Matthew J. Ellis,Steven A. Carr +37 more
TL;DR: It is demonstrated that proteogenomic analysis of breast cancer elucidates functional consequences of somatic mutations, narrows candidate nominations for driver genes within large deletions and amplified regions, and identifies therapeutic targets.
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Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.
Chenfang Dong,Tingting Yuan,Yadi Wu,Yifan Wang,Teresa W.-M. Fan,Sumitra Miriyala,Yiwei Lin,Jun Yao,Jian Shi,Tiebang Kang,Pawel Lorkiewicz,Daret K. St. Clair,Mien Chie Hung,Mien Chie Hung,B. Mark Evers,Binhua P. Zhou +15 more
TL;DR: This study indicates that the loss of FBP1 is a critical oncogenic event in EMT and BLBC.
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Ki67 expression in breast cancer. Correlation with prognostic markers and clinicopathological parameters in Saudi patients.
Mohamed A. Elkablawy,Abdulkader M. Albasri,Rabab Mohammed,Akbar S. Hussainy,Magdy M. Nouh,Ahmed Safar Alhujaily +5 more
TL;DR: The Ki67 PI is significantly higher in Saudi BC patients comparing with the reported literature, and was highest in the HER-2 and luminal-B molecular subtypes.
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
Yixiao Feng,Yixiao Feng,Mia Spezia,Shifeng Huang,Shifeng Huang,Chengfu Yuan,Chengfu Yuan,Zongyue Zeng,Zongyue Zeng,Linghuan Zhang,Linghuan Zhang,Xiaojuan Ji,Xiaojuan Ji,Wei Liu,Wei Liu,Bo Huang,Bo Huang,Bo Huang,Wenping Luo,Wenping Luo,Bo Liu,Bo Liu,Yan Lei,Yan Lei,Scott Du,Akhila Vuppalapati,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Guosheng Ren +29 more
TL;DR: Emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer.
References
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Journal ArticleDOI
Molecular portraits of human breast tumours
Charles M. Perou,Therese Sørlie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,Christian A. Rees,Jonathan R. Pollack,Douglas T. Ross,Hilde Johnsen,Lars A. Akslen,Øystein Fluge,Alexander Pergamenschikov,Cheryl A. Williams,Shirley Zhu,Per Eystein Lønning,Anne Lise Børresen-Dale,Patrick O. Brown,David Botstein +17 more
TL;DR: Variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals were characterized using complementary DNA microarrays representing 8,102 human genes, providing a distinctive molecular portrait of each tumour.
Journal ArticleDOI
A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Tsvee Lapidot,Christian Sirard,Josef Vormoor,Barbara Murdoch,Trang Hoang,Julio R. Caceres-Cortes,Mark D. Minden,Bruce Paterson,Michael A. Caligiuri,John E. Dick +9 more
TL;DR: This in vivo model replicates many aspects of human AML and defines a new leukaemia-initiating cell which is less mature than colony-forming cells.
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