Journal ArticleDOI
IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma
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TLDR
IL-17 is suggested to be a novel indicator of prognosis in the patients with colorectal carcinoma and could serve as a novel therapeutic target for coloreCTal carcinomas, and the results indicate that IL-17 producing cells may facilitate development of colorective carcinoma by fostering angiogenesis via promote VEGF production from cancer cells.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2011-04-08. It has received 310 citations till now. The article focuses on the topics: Mouse model of colorectal and intestinal cancer & Angiogenesis.read more
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The immune contexture in human tumours: impact on clinical outcome
Wolf H. Fridman,Franck Pagès,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Jérôme Galon +5 more
TL;DR: In this Opinion article, the context-specific nature of infiltrating immune cells can affect the prognosis of patients is discussed.
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Chronic inflammation and cytokines in the tumor microenvironment.
TL;DR: The role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis are explored.
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The IL-17 Family of Cytokines in Health and Disease.
TL;DR: The functions of the interleukin 17 family are discussed, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects ofIL-17 signal transduction regulation.
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Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
Stefanie Kirchberger,Daniel J. Royston,O Boulard,Emily E. Thornton,Fanny Franchini,Rose L. Szabady,Oliver J. Harrison,Fiona Powrie +7 more
TL;DR: Neutralization of IL-22 production from colonic innate lymphoid cells reduces dysplasia in bacterial-induced colon cancer by reducing proliferation of epithelial cells via reduced activation of Stat3.
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IL-17 family: cytokines, receptors and signaling.
TL;DR: The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved inIL-17 mediated host defense and IL- 17-driven autoimmune conditions.
References
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Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
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Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
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IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
TL;DR: The factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.
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TH17 cells in development: an updated view of their molecular identity and genetic programming.
TL;DR: The current knowledge of the unique gene expression, cytokine-mediated regulation and transcriptional programming of TH17 cells is summarized, and the personal perspectives on the future studies that are required to elucidate this lineage in more detail are provided.
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Interleukin-17 promotes angiogenesis and tumor growth.
Muneo Numasaki,Jun Ichi Fukushi,Mayumi Ono,Satwant K. Narula,Paul J. Zavodny,Toshio Kudo,Paul D. Robbins,Hideaki Tahara,Michael T. Lotze +8 more
TL;DR: A novel role for IL-17 is revealed as a CD4 T-cell-derived mediator of angiogenesis that stimulates vascular endothelial cell migration and cord formation and regulates production of a variety of proangiogenic factors.