Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TLDR
In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.About:
This article is published in The Lancet.The article was published on 1998-02-28. It has received 2505 citations till now. The article focuses on the topics: Pervasive developmental disorder & Lymphoid hyperplasia.read more
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Tragedy, utopia and medical progress
TL;DR: It is proposed that the problem of “medicalisation” is better understood in a framework of tragedy than in a utopian one, because in utopia, it is presupposed that there is an error behind every setback and every side effect.
Journal ArticleDOI
Setting the Record Straight: Vaccines, Autism, and the Lancet
TL;DR: A father, physician, and editor of a journal focused on communicating health ethically, I remained concerned about the challenges, fear, and pain of individuals and families with autistic children and joined with Jon Clemens at the World Health Organization to co-author an article published in the Journal of Medical Ethics.
Journal Article
Autism and infection/immunization episodes in Japan.
TL;DR: The possible association of autism with infection or immunization has been reported since the 1970s and three of nine autistic children born in United Kingdom were positive for measles H gene as determined by RT-PCR.
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MMR: science and fiction.
TL;DR: Horton's book is best in its description of the events surrounding the publication of the paper and the subsequent debate, and gives insight into the tensions affecting Wakefield, Wakefield’s coauthors, other doctors at the Royal Free Hospital and Medical School and, of course, the Editor of The Lancet.
References
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Journal ArticleDOI
Alpha-1-antitrypsin, autism, and cœliac disease
Book
The Autistic Spectrum
TL;DR: A simple system of subgrouping based solely on a description of the type of social impairment will be used, which avoids the confusion inherent in trying to identify the named syndromes.
Journal ArticleDOI
Abnormal intestinal permeability in children with autism.
Patrizia D'Eufemia,Mauro Celli,R. Finocchiaro,Lucia Pacifico,L Viozzi,M. Zaccagnini,Ettore Cardi,Omero Giardini +7 more
TL;DR: It is speculated that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities.
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A neurochemical theory of autism
TL;DR: Panksepp et al. as discussed by the authors put forward the idea that autism is an emotional disturbance arising from an upset in the opiate systems in the brain, and hence proposed, as a possibility, opiate antagonist therapy for the autistic syndrome.