Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TLDR
In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.About:
This article is published in The Lancet.The article was published on 1998-02-28. It has received 2505 citations till now. The article focuses on the topics: Pervasive developmental disorder & Lymphoid hyperplasia.read more
Citations
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Journal ArticleDOI
Quantitative PCR pitfalls: the case of the human placenta.
Dave Lanoix,Andrée-Anne Lacasse,Joey St-Pierre,Sean C. Taylor,Maude Ethier-Chiasson,Julie Lafond,Cathy Vaillancourt +6 more
TL;DR: The data presented here show how RNA quality and appropriate reference gene selection is not only important to obtain accurate and reproducible RT-qPCR data but how different and even opposite results can be reported if the key steps outlined in the MIQE guidelines are not followed.
Journal ArticleDOI
Views on the peer review system of biomedical journals: an online survey of academics from high-ranking universities.
TL;DR: Female academics, experience of personal attacks and imposition of unnecessary references by reviewers were related to disagreement about fairness of the peer review system of biomedical journals.
Book
Measuring and Reasoning: Numerical Inference in the Sciences
TL;DR: In Measuring and Reasoning, Bookstein examines the way ordinary arithmetic and numerical patterns are translated into scientific understanding, showing how the process relies on two carefully managed forms of argument: abduction and consensus as mentioned in this paper.
Journal ArticleDOI
Autism: its recognition, early diagnosis, and service implications
TL;DR: A generation ago, most children with autism did not receive a diagnosis until the school-age years, but nowadays it is much more usual for diagnoses to be made in the preschool period, although it tends to be later when there is not an associated intellectual disability.
Journal ArticleDOI
Parent-Reported Gastro-intestinal Symptoms in Children with Autism Spectrum Disorders
Susie Chandler,Iris Carcani-Rathwell,Tony Charman,Andrew Pickles,Tom Loucas,David Meldrum,Emily Simonoff,Peter B. Sullivan,Gillian Baird +8 more
TL;DR: Parents report more GI symptoms in children with ASD than children with either SEN or TD children but the frequency of reported symptoms is greater in the past than currently in all groups, and no association was found between GI symptoms and intellectual ability, ASD severity, ASD regression or limited or faddy diet.
References
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Journal ArticleDOI
Alpha-1-antitrypsin, autism, and cœliac disease
Book
The Autistic Spectrum
TL;DR: A simple system of subgrouping based solely on a description of the type of social impairment will be used, which avoids the confusion inherent in trying to identify the named syndromes.
Journal ArticleDOI
Abnormal intestinal permeability in children with autism.
Patrizia D'Eufemia,Mauro Celli,R. Finocchiaro,Lucia Pacifico,L Viozzi,M. Zaccagnini,Ettore Cardi,Omero Giardini +7 more
TL;DR: It is speculated that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities.
Journal ArticleDOI
A neurochemical theory of autism
TL;DR: Panksepp et al. as discussed by the authors put forward the idea that autism is an emotional disturbance arising from an upset in the opiate systems in the brain, and hence proposed, as a possibility, opiate antagonist therapy for the autistic syndrome.