Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TLDR
In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.About:
This article is published in The Lancet.The article was published on 1998-02-28. It has received 2505 citations till now. The article focuses on the topics: Pervasive developmental disorder & Lymphoid hyperplasia.read more
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GRADE guidelines: 3. Rating the quality of evidence
Howard Balshem,Mark Helfand,Mark Helfand,Holger J. Schünemann,Andrew D Oxman,Regina Kunz,Jan Brozek,Gunn Elisabeth Vist,Yngve Falck-Ytter,Joerg J Meerpohl,Susan L Norris,Gordon H. Guyatt +11 more
TL;DR: The approach of GRADE to rating quality of evidence specifies four categories-high, moderate, low, and very low-that are applied to a body of evidence, not to individual studies.
Journal ArticleDOI
Identification and Evaluation of Children With Autism Spectrum Disorders
TL;DR: This report addresses background information, including definition, history, epidemiology, diagnostic criteria, early signs, neuropathologic aspects, and etiologic possibilities in autism spectrum disorders, and provides an algorithm to help the pediatrician develop a strategy for early identification of children with autism Spectrum disorders.
Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Journal ArticleDOI
The Genetics of Autism
TL;DR: Significant evidence is found for multiple interacting genetic factors as the main causative determinants of autism and for interactions between multiple genes cause "idiopathic" autism but that epigenetic factors and exposure to environmental modifiers may contribute to variable expression of autism-related traits.
Book ChapterDOI
Global Burden of Disease
TL;DR: This article is reproduced from the previous edition, volume 3, pp. 59–71, of Elsevier Inc.
References
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Measles vaccination and neurological events
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Polymerase chain reaction detection of the hemagglutinin gene from an attenuated measles vaccine strain in the peripheral mononuclear cells of children with autoimmune hepatitis.
TL;DR: It is demonstrated that children with autoimmune hepatitis can have persistence of the vaccine strain in vivo for many years after vaccination.
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Problems with the serum vitamin b12 assay
J.M. England,J.C. Linnell +1 more
TL;DR: The assay of serum cobalamin is too insensitive and non-specific for a low level to be used as the sole criterion of vitamin B12 deficiency; the haemopoietic and biochemical sequelae of vitaminB12 deficiency also correlate poorly with the serum level.
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A sensitive micromethod for the routine estimation of methylmalonic acid in body fluids and tissues using thin layer chromatography.
TL;DR: A routine method using thin-layer chromatography on cellulose, locating the separated MMA zones by coupling with a diazo reagent and quantitating the results by densitometric scanning of a photocopy of the chromatogram on transparency film has potential for the simultaneous estimation of MMA, other organic acids, methylmalonyl coenzyme A and creatinine.
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