Journal ArticleDOI
In utero exposure to valproic acid and autism — A current review of clinical and animal studies
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TLDR
A review of clinical studies that examined pregnancy outcomes of VPA use as well as the related animal studies that investigated anatomical, behavioral, molecular, and physiological outcomes related to in utero VPA exposure.About:
This article is published in Neurotoxicology and Teratology.The article was published on 2013-03-01. It has received 334 citations till now. The article focuses on the topics: Autism.read more
Citations
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Journal ArticleDOI
Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder.
TL;DR: This work underscores the need for studying both sexes in ASD animal models and validates the use of the VPA model in the quest for mechanistic understanding of aberrant attentional functions and for evaluating suitable therapeutic targets.
Book ChapterDOI
Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism.
Peter Ranger,Bart A. Ellenbroek +1 more
TL;DR: The connection between VPA and ASD is discussed, the VPA animal model of ASD is evaluated, and the possible molecular mechanisms underlying VPA's teratogenic properties are described.
Journal ArticleDOI
Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism
Monica Regina Favre,Deborah La Mendola,Julie Meystre,Dimitri Christodoulou,Melissa Cochrane,Henry Markram,Kamila Markram +6 more
TL;DR: It is found that predictable environmental enrichment prevented the development of hyper-emotionality in the VPA-exposed group, while unpredictable enrichment did not, and it is demonstrated that unpredictable environments can lead to negative outcomes, even in the presence of environmental enrichment.
Journal ArticleDOI
Autism and epilepsy: Exploring the relationship using experimental models
Carl E. Stafstrom,Tim A. Benke +1 more
TL;DR: Animal models can be informative in sorting out the medical and behavioral complexities in autism and epilepsy and the relationship between them, and it is anticipated that mutation- and pathway-specific targeted treatments can be developed.
Journal ArticleDOI
Bench to bedside review: Possible role of vitamin D in autism spectrum disorder
Fei-Yong Jia,Ling Shan,Bing Wang,Hong-Hua Li,Chunyue Miao,Zhida Xu,Ching Po Lin,Khaled Saad,Khaled Saad +8 more
TL;DR: A review of the recent advances in vitamin D deficiency during pregnancy and early childhood and the possible role of vitamin D in autism spectrum disorder is addressed.
References
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Journal ArticleDOI
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Martin Göttlicher,Saverio Minucci,Ping Zhu,Oliver H. Krämer,Annemarie Schimpf,Sabrina Giavara,Jonathan P. Sleeman,Francesco Lo Coco,Clara Nervi,Pier Giuseppe Pelicci,Thorsten Heinzel +10 more
TL;DR: Valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients, and tumor growth and metastasis formation are significantly reduced in animal experiments, suggesting that it might serve as an effective drug for cancer therapy.
Journal ArticleDOI
Epidemiological surveys of autism and other pervasive developmental disorders: an update.
TL;DR: There is evidence that changes in case definition and improved awareness explain much of the upward trend of rates in recent decades, however, available epidemiological surveys do not provide an adequate test of the hypothesis of a changing incidence of PDDs.
Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008
TL;DR: This report provides updated ASD prevalence estimates from the 2008 surveillance year, representing 14 ADDM areas in the United States and characteristics of the population of children with ASDs are described, as well as detailed comparisons of the 2008 findings with those for the 2002 and 2006 surveillance years.
Journal ArticleDOI
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
TL;DR: A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.
Journal ArticleDOI
Behavioral alterations in rats prenatally exposed to valproic acid: Animal model of autism
TL;DR: Interestingly, all behavioral aberrations described in this paper appear before puberty, which could distinguish the VPA rat model of autism from other animal models of neurodevelopmental disorders, especially rodent models of schizophrenia.